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HUMAN PHYSIOLOGY
AN INTEGRATED APPROACH Dee Unglaub Silverthorn, Ph.D.
PowerPoint Lecture Slide Presentation by Dr. Howard D. Booth, Professor of Biology, Eastern Michigan University
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings
To ECF
Gradient
Diffuses to blood
Collecting Duct: Aldosterone regulates
Aldosterone: steroid H from adrenal cortex Stimulates Na+ uptake (& K+ secretion)
channel synthesis
Angiotensin Pathway: Maintains BP , Volume & Osmolarity Angiotensinogen, ANGI, ANG II, rennin, & ACE
PLAY
Protein damage
CNS depression Alkalosis: plasma pH Hyperexcitability CNS & heart
PLAY
Type A Intercalated cells excrete H+ absorb HCO3 Type B intercalated cells absorb H+ secrete HCO3-
Summary
Electrolyte balance depends on integration of circulatory, excretory and behavioral physiology
Water recycling and ECF/plasma balance depends on descending loop of Henle and vasopressin regulated collecting duct for conservation Osmolarity depends on aldosterone and angiotensin pathway to regulate CNS & endocrine responses Along with respiration, proximal tubule and collecting duct cells reabsorb or excrete H+ & HCO3- to balance pH
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings