Beruflich Dokumente
Kultur Dokumente
Treatment of Postviral Olfactory Loss With Glucocorticoids, Ginkgo biloba, and Mometasone Nasal Spray
Beom Seok Seo,Hyun Jong Lee, Ji-Hun Moo,Chul Hee Lee, Chae-Seo Rhee,Jeong-Whun Kim
Background
Olfactory disorder mechanism is not clearly understood Which viruses cause postviral olfactory loss is unknown The role of the olfactory neural system in postviral olfactory loss is unknown
Questions
Does treatment using prednisolone plus ginkgo biloba significanly improved for postviral olfactory loss?
The Purpose
To analyze the efficacy of treating postviral olfactory loss with glucocorticoid, Ginkgo biloba and mometasone nasal spary
Hypotesis
There is significant difference between the ginkgo biloba and non ginkgo biloba group of treating postviral olfactory loss.
Design
Place Time
Chemosensory Outpatient Clinic of Seoul National University Bundang Hospital, Seongmnam, Korea
Inclusion criteria
Exclusion criteria
History of upper
Inclusion criteria
A visit within 12 month after onset of postviral
exclusion criteria
Presence of nasal discharge
olfactory loss
No evidence of sinus Inflammation on computed tomographic osteomeatal or paranasal sinus view
Allergic rhinitis
Chronis rhinosinusitis
Procedure
monotherapy
Combination therapy
Monometasone furoat nasal spray 2 puff pernostril twice daily for 4 weeks
Result
After treatment ( score change) BTT CCSIT Monotherapy 2.2 1.7 Combination therapy 2.9 (P=.22) 2.7 (P=.11)
Result
After Therapy ( the Monotherapy threatment respon) Modification Therapy
BTT Therpy
CCSIT
Discussion
This study to analyze the efficacy of treating postviral olfactory loss with glucocorticoids, Ginkgo biloba and mometasone furoate nasal spray All patient underwent olfactory function test such BTT, CCSIT Postviral olfactory loss were treated with oral prednisolon,Ginkgo biloba and mometasone furoate nasal spray
Critical apraisal
1. Is an estimate of the treatment effect given ? yes 2. Is it of clinical importance ? yes
10. Were loses to follow-up low ? yes 11. Were the treatment groups similar in important factor's at the start of the trial? yes
13. Were patients, health care workers and investigator 'blind' to treatment? no 14.Was assessment of outcome 'blind'? no
15. Was the main analysis on 'intention to treat'? Yes 16. Were appropriate statistical methods used? Yes
Conclusion
Thank you