Bioreactor Engineering

CBE654 EH222 6A & 6B Introductory lecture on Bioreactors (current technology and informations)

Amizon Azizan

Faculty of Chemical Engineering

Lesson Plan
Lesson plan
CBE654_BIOREACTOR_ENGINEERING_LE SSON_PLAN_5Mac.doc

Introduction
Amizon Students

Bioreactor Engineering
Introductions
Applications Examples of bioreactors
Stirred (bioreactor/fermenter)
Infors, Sartorius etc http://www.infors-ht.com/index.php/en/ http://www.sartoriusstedim.com/WW/en/fermentation_and_cell_cultivation/6ehw52oyd 0c_artikel_liste.htm Examples of autoclavable bioreactor, in situ sterilizable bioreactor, single use bioreactor (Sartorius)

Microbioreactor (Biolector, RAMOS, BCpreFerm etc)

Bioreactor Engineering
Industrial scale bioreactor
Malaysian scenario http://www.chemicals-technology.com/projects/sirim-bioplastics-pilot-plant/sirimbioplastics-pilot-plant3.html The Malaysian designed SIRIM Bioreactor Technology at the pilot plant has integrated production processes and bioreactor facilities producing 2,000l of different PHA materials. Image courtesy of SIRIM Berhad.
Polyhydroxyalkanoates or PHAs are linear polyesters produced in nature by bacterial fermentation of sugar or lipids. They are produced by the bacteria to store carbon and energy. More than 150 different monomers can be combined within this family to give materials with extremely different properties.[1] These plastics are biodegradeable and are used in the production of bioplastics.

Contact person Adida Zuraida, SIRIM Incubation Centre, Lot 10, Kawasan MIEL, Fasa 2, Jalan Beremban 15/12, 40000 Shah Alam, Selangor SIRIM Bioplastics Pilot Plant WORD.docx Alpha Biologics alpha biologics.docx

Alpha Biologics

Bioreactors can be operated in batch, fedbatch or perfusion mode. The facility has seven bioreactors. The bioreactors range from 10 to 500l capacity. There is a buffer preparation unit with 50l, 120l, 250l and 1000l preparation vessels.

Bioreactor Engineering
Industrial scale bioreactor World scenario
Bioethanol plant
Brochure5_Bioethanol_low_res.pdf Production of bioethanol in the UE.docx

Bioreactor-fermentation

Bioreactors
Autoclavable bioreactors
Flyer-Minifors-(en).pdf Flyer-Labfors-5-(en).pdf

Bioreactor

Bioreactor

Other schematic diagram of a reactor

Bioreactor
In situ sterilizable bioreactors Flyer-Techfors-(en).pdf Broch_BIOSTATCplus_SBI1505-e_pdf.pdf

Bioreactors
Single use bioreactors
http://www.sartoriusstedim.com/WW/en/Single-useBioreactors/9rdq4s5bimw_artikel_liste.htm Broch_BIOSTATCultiBagRMcomp_SBT1501e.pdf Broch_BIOSTAT_Standard_Systems_Overvie w_SBI1511-e.pdf Single use technology Xcellerex.pdf

Fermentation
Principles_of_Fermentation_Technology.pdf

Bioreactor design

Bioreactor design:
Agitator for gas-phase mixing, air dispersion, oxygen transfer, heat transfer, suspension of solid particles.

Suitable for high viscosity broth

Page 179

Bioreactor : agitator

Bioreactor : agitator