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CiVentiChem (India) Private Limited

(Formerly Known as Indus BioSciences Private Limited)

Global operations in the USA and India with project management, 1 IP control and local solutions at our USA headquarters

Highlights of Presentation
History Business Overview Services and Capabilities Management Experience and Chemistry Expertise Chemistry Specialties & Capabilities Bulk Projects Performed in Plant Chemistry Experience
Examples in Med. Chem & P R&D

Proprietary Building Blocks

Facilities
Global operations in the USA and India with project management, 2 IP control and local solutions at our USA headquarters

History
1994 - Founded in RTP, North Carolina 1999 Expanded to Larger Laboratory 2000 Reached 12 Scientists at USA 2001 R&D Laboratories Opened in India with 5 Chemists 2009 Launch of our Plant in Hyderabad, India 2011 cGMP Synthesis lab in RTP, NC, USA
Global operations in the USA and India with project management, 3 IP control and local solutions at our USA headquarters

Business Overview
HQ: Services: People: Facilities: RTP, North Carolina Chemistry 80 Experienced Scientists & Admin USA and India
Discovery & Synthetic Chemistry, Process Development, Manufacturing & Analytical Services

RTP, North Carolina and Hyderabad, India 50,000 Sq Ft Total Technical Facilities

Customers: Around 150


including 10 of world Top 20 Pharma; 45 Biotechnology Companies.

Integrated Management Systems ISO-9001-2008 (QMS), 14001-2004 (EMS) and 18001-2007 (OSHA)
Global operations in the USA and India with project management, 4 IP control and local solutions at our USA headquarters

Our Role in Drug Development


Biological Target Screening Screening Hits Leads Drug candidate candidate Pre clinical Clinical Clinical Launch

Associated Chemistry

Screening Compounds

Parallel Synthesis

Medicinal Chemistry

Custom Synthesis

Process Scale - up

Pilot Plant

Manufacturing

CiVentiChem USA & India Peakdale Molecular

CiVentiChem India Collaborators

RESEARCH CHEMISTRY
Medicinal Chemistry Focused Libraries Reference Standards & Metabolites Lead Compounds & NCEs Lead Optimization Intermediates and Building Blocks available and in-stock

DEVELOPMENT CHEMISTRY

PRODUCTION CHEMISTRY

Rapid Initial Scale-up to first Kg Pilot Development Process Research & Manufacture Development Process Research & Feasibility Studies Development Pilot Development Manufacture Contract Manufacturing Manufacture Intermediatess & Manufacture Intermediates & APIs APIs cGMP &Global Non-GMP Protocols operations in the USA and India with project management,
5 IP control and local solutions at our USA headquarters

Global Advantages
Flexibility of Choice USA or India or BOTH !! Project Type Deadline Output Scale or Volume Research Requirements Expertise Requirements Communication and Project Control Lowest Cost
Global operations in the USA and India with project management, 6 IP control and local solutions at our USA headquarters

Business Overview - Clients


No. of clients 150 No. of Pharma Clients 10 (from world top 20 Pharma Companies) No. of Biotech Clients 10 + No. of Catalogue Companies 5 + No. of Fine Chemical Companies 10 +

Global operations in the USA and India with project management, 7 IP control and local solutions at our USA headquarters

Services and Capabilities


Global operations in the USA and India with project management, 8 IP control and local solutions at our USA headquarters

Research Chemistry Services


Medicinal Chemistry Synthesis of Focused Libraries & Analogues Synthesis of Reference Standards & Metabolites Synthesis of Lead Compounds & NCEs Lead Optimization & Parallel Synthesis Novel Template Molecules Ready for Purchase

Global operations in the USA and India with project management, 9 IP control and local solutions at our USA headquarters

Development/Manufacturing Services
Rapid Initial Scale-up to 1st Kilogram Route Scouting Process Development & Optimization Manufacture of Intermediates API ready starting materials
Global operations in the USA and India with project management, 10 IP control and local solutions at our USA headquarters

Management Experience

Global operations in the USA and India with project management, 11 IP control and local solutions at our USA headquarters

Management Team
Bhaskar Venepalli, Ph. D
Chief Executive Officer
Professional Experience

Vasu (Srinivas) Chittineni, Ph. D


Chief Technical Officer
Professional Experience

25 + Years experience in fine chemicals including 13 20 + Years experience in synthetic organic Yrs experience in R&D, new product development & Business Management at Eastman Kodak-Eastman Chemical Company Expertise in CRAMS & Fine Chemicals Founder of Civentichem in 1994 in USA Education Ph.D. from Osmania University, Hyderabad (IND) Post Doctoral Research at University of Education Ph.D. from Kakatiya University (IICT, Hyderabad, INDIA) Post Doctoral Research at Duke University , NC, USA
Global operations in the USA and India with project management, 12 IP control and local solutions at our USA headquarters

chemistry Expertise in Complex Organic Syntheses, Chiral & Carbohydrate Chemistry Co founder of Civentichem in 1994

Southampton (England) & Rockefeller University, New York, (USA)

Management Team
Venkataiah Sunku, Ph. D Managing Director
Professional Experience

Venu (Venugopal) Veeramaneni, Ph. D Head R&D and BD&PM


Professional Experience

30 + Years experience in pharma including 8


Yrs experience as Director R&D at Aurobindo Pharma (India) Expertise in Process Development & Plant Scale operations Developed processes for 22 bulk drugs & Transferred to Mfg Plants

18 Years experience in Drug Discovery


(Medicinal &Synthetic Organic Chemistry. Including 11 yrs at Dr. Reddys Discovery Research. Expertise in Synthesis of NMEs & Complex Organic Syntheses

Education Education Ph.D. in Chemistry from Osmania University, Hyderabad (INDIA). 6 Publications & Patents Ph.D. in Chemistry from JNTUniversity (DRF, Hyderabad, INDIA) 25 Publications, Patents & Presentations
Global operations in the USA and India with project management, 13 IP control and local solutions at our USA headquarters

Research Team @ Civentichem India


Hari Prasad Chittineni, Ph.D. Section Head, Process Development 14 Yrs Experience in Carbohydrate, Heterocyclic Chemistry including 4 Yrs in AVRA Synthesis Expertise in Process Development M.Sc. From Osmania University Ph.D. from JNT University 7 Publications & Patents Venkat Laxman Rao Cilamkoti, Ph.D. Section Head, Medicinal Chemistry 16 Yrs experience in Multi Step Organic Synthesis including 8 Yrs in Dr Reddys Discovery Research Expertise in Medicinal & Small scale Chemistry M.Sc. From Osmania University Ph.D. from Osaka University, Japan 9 Publications & Patents Shyam Group Leader 8 Yrs Exp in Med. Chem. & Small Scale M.Sc. from Osmania University RC Sekar Group Leader 8 Yrs Exp in Med. Chem. & Small Scale M.Sc. from Osmania University Rajitha Group Leader 8 Yrs Exp in New Building Blocks M.Sc. from Osmania University

Vineel, Ph.D Group Leader 5 Yrs Exp in Sugar & Chiral Chemistry. Ph.D. from JUNTU

Mamatha Group Leader 8 Yrs Exp in Azaindole & Indazole Chemistry M.Sc. from Osmania University

Gopal Group Leader 8 Yrs Exp in Process & Scale Up Chemistry M.Sc. from Osmania University

Global operations in the USA and India with project management, 14 IP control and local solutions at our USA headquarters

Research Team @ Civentichem India


Venkataiah, Ph.D. MD Venugopal Rao Veeramaneni, Ph.D. Head R&D and PM

Hari Prasad Chittineni, Ph.D. Section Head, Process Chemistry Vineel Group Leader PR&D Gopal Group Leader PR&D Mamatha Group Leader PR&D Shyam

Venkat Laxman Rao C, Ph. D.

Section Head, Med. Chem


RC Sekar Group Leader Med. Chem. Rajitha Group Leader Med. Chem.

Group Leader Med. Chem.

2 SRA
1 RA

2 SRA
2 RA

2 SRA
1RA

2 SRA
1RA

2SRA
1RA

2SRA
1RA

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Research Team @ Civentichem India


Venkataiah, Ph.D. MD
Analytical R&D (6 AR&D Chemists) Vinay Kumar GM, Plant Operations Admin & Finance (6 Persons)

Manager, Maintenance (9 Persons)

Plant Production In-Charge

Stores

Purchase

Safety

Shift in-Charge & Chemists/Operator (9 Persons)


Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Chemistry Expertise & Performance Matrix


Global operations in the USA and India with project management, 17 IP control and local solutions at our USA headquarters

Chemistry Specialties
Sugar Molecules Chiral Catalysts and Reagents

Reagents for peptide formation


Novel Hetero cyclic compounds for supporting all the stages in drug discovery. Pyrazoles, Isoxazole, Oxazoles, Pyrazines, Pyridazines, Pyrimidines, Pyrrolopyrimidine, Azaindoles, Indazoles,

Piperidinopyrimidines and Heterocycles having Spiro group


Chiral Binaphthols & Boronic Acids
Global operations in the USA and India with project management, 18 IP control and local solutions at our USA headquarters

General Reactions - mg to Kg scale Grignard Reactions Up to 50 kg of Mg charge Bromination mg to multi Kg scale Hydrogenation Reactions 350L SS, 30 kg/cm Transition Metal Reactions Suzuki coupling (0.5Kg, 1Kg to 25Kg Scale)
Buchwald-Hartwig Coupling (5g & 500g Scale) Negishi coupling (150g & 250g) Sonogashira reaction (1Kg Scale) Stille coupling (10g Scale)

Chemistry Capabilities

Enzymatic Resolutions Reactions in Aqueous medium Phosgenations using triphosgene


Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Bulk Projects Performed in Plant


S.No. Project Code 1 2 3 4 5 6 7 8 IB-205/151 IB-205/284 IB-150/011 IB-111/280 IB-111/291 IB-150/214 IB-206/263 IB-080/319 Quantity 45Kg 120Kg 425Kg & 415Kg 15Kg & 27Kg 15Kg & 27Kg 5Kg & 7Kg 10Kg 6Kg & 12Kg No. of Steps 2 2 4 3 3 7 1 2 Month of completion Oct, 2009 Nov, 2009 Jan & Oct 2010 Jan, 2010 Jan, 2010 Feb & Nov 2010 Feb, 2010 March, 2010 Remarks/Key Chemistries Iodination & amide formation Indole Acylation Methylsulfonation & chlorination Bromination & Phosphonate Chemistry Bromination & Phosphonate Chemistry Cyclopropanation & Protection of Amine Hydroxymethylation Formyl pyrazoles

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Bulk Projects Performed in Plant


S.No. 9 10 11 12 13 14 15 16 Project Code IB-206/320 IB-323/282 IB-323/086 IB-206/263 IB-313/275 IB-150/333 IB-213/338 IB-150/014 Quantity 21Kg/ 35Kg 5Kg/30Kg 7Kg 10Kg/ 100Kg 3X100Kg 15Kg 75Kg 24Kg No. of Steps 4 10 5 1 1 2 2 9 Month of completion March & July 2010 April & Nov 2010 April 2010 April & june 2010 3 Times in 2010 June, 2010 June, 2010 Sept, 2010 Remarks/Key Chemistries Amino acid Chemistry Benzofuran formation, Suzuki coupling & Reduction Azaindole Chemistry & Catalytic hydrogenation Hydroxymethylation Preparation Phase Transfer Catalyst Nitration & etherification Cyclopropanation Nitration, Reduction and Migration

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Bulk Projects Performed in Plant


S.No. 17 18 19 20 21 22 23 24 Project Code IB-080/293 IB-266/267 IB-036/206 IB-372/266 BAL-PH IB-398/404 IB-079/176 IB-373/399 Quantity 10Kg 45Kg 10Kg / 100Kg 5Kg , 35Kg & 35Kg 186Kg 10Kg 35Kg 48Kg No. of Steps 7 3 4 2 2 3 1 1 Month of completion Oct, 2010 Oct, 2010 Oct, 2010 Dec, 2010 & Feb, 2011 Jan, 2011 Feb, 2011 Feb, 2011 Feb, 2011 Remarks/Key Chemistries Azaindole Chemistry, Nitration & Bromination Bromination & Selective Reduction Grignard Reaction Bromination & Thiazole formation Critical Reduction Phosphonate Chemistry Pyrazole formation Cyclization

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Bulk Projects Performed in Plant


S.No. Project Code Quantity No. of Steps Month of completion Remarks/Key Chemistries

25
26

IB-416-2053595
IB-426-427025 IB-147-1503988 IB-455-1505025 IB-407-1505628 IB-232-4504062

76Kg
60Kg

3
4

April, 2011
June, 2011

Cyclization
Modified Reduction method to avoid expensive Pd Charcoal Synthesized Starting Material instead of buying expensive KSM Synthesized Starting Material instead of buying expensive KSM Benzofuran formation, Suzuki coupling & Reduction

27

60Kg

July, 2011

28

16Kg

July, 2011

29 30

45Kg 6Kg

10 5

July, 2011 July, 2011

Target is Very Useful KSM for Anti Viral APIs. And process is Global operations in the USA and India with project performed inmanagement, water
IP control and local solutions at our USA headquarters

Bulk Projects Performed in Plant


S.No. 31 Project Code Quantity 30Kg No. of Steps 1 Month of completion August, 2011 Remarks/Key Chemistries Salt preparation as per clients typical specifications Salt preparation as per clients typical specifications Salt preparation as per clients typical specifications

CVI-429-4287024
32 CVI-476-428092 33 CVI-431-4287026 15Kg 1 August, 2011 30Kg 1 August, 2011

34
CVI-431-4287025 35 IB-471-472-088 36 CVI-432-1505025

15Kg

August, 2011

Salt preparation as per clients typical specifications


Handling of use amount of TFA (which is minimized to 30%)

10Kg & 25Kg 40Kg

August, 2011 & Jan 2012

November, Synthesized Starting Material 2011 instead of buying expensive Global operations in the USA and India with project management, KSM IP control and local solutions at our USA headquarters

Performance of our Research Team


2007 2008 2009 2010 2011

No. of Steps Vs Compounds


162 336 236 164 2009 2010 2011

136

108 35 50 6-10 Steps

9 20 21 11-15 Steps

22 16 5 15 and above

113 95 80 72 66 60 99 93 84 85

1-5 Steps

75
62

41 30 35 28 22 22 15 9 19 19 18 8 23 12 14

2 4

Up to 1g

1.1g to 10g

11g to 100g

101g to 1000g

1.1Kg to 10Kg

11Kg to 50Kg

51Kg to 100Kg & above

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Quality and Integrated Management Systems

Global operations in the USA and India with project management, 26 IP control and local solutions at our USA headquarters

ISO Certifications
CiVentiChem India has successfully obtained the following certifications

Currently follow Integrated Management Systems


ISO-9001-2008 certification for Quality Management Systems ISO-14001-2004 certification for Environmental Management Systems ISO-18001-2007 certification for Occupational, Health and Safety

Management Systems (OSHA)

Global operations in the USA and India with project management, 27 IP control and local solutions at our USA headquarters

Chemistry Experience - Case Studies

Global operations in the USA and India with project management, 28 IP control and local solutions at our USA headquarters

Route Scouting and Discovery Support Erlotinib Analogue


Client wanted a compound with a reactive functional group Re-designed the synthesis and delivered the product

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Med Chem Support/Route Scouting

C-imatinib analogue
Client wanted analog with a reactive functional group Re-designed the synthesis with a new route and delivered the product with NH2 and maleimido groups

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Med Chem Support-Focus Libraries

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Med Chem Support-Focus Libraries

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Med Chem Support-Focus Libraries

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Reference Standards for Med Chem Support

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Reference Standards for Med Chem Support

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

New Route & Process Development Hexahydrofuro[2,3-b]furan-3-ol moiety


Bis-THF alcohol -A Key intermediate in many antiviral drugs Our goal: Develop a new route for use in Med Chem Then develop a process for manufacturing

NCE

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

New Route & Process Development Hexahydrofuro[2,3-b]furan-3-ol moiety

Reported synthetic route

Problems with enantiomeric purity Scalability


Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

New Route & Process Development Hexahydrofuro[2,3-b]furan-3-ol moiety


New Route Development to make chiral alchol

Process Development

Initial Goal: Make small quantity to make 100 gm of API After this is delivered, client wanted to file for IND, hence needed 10 Kg No luxury of time as it was needed urgently Brute forced the synthesis and delivered the product Two enantiomers were separated by column chromatography
Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

New Route & Process Development Hexahydrofuro[2,3-b]furan-3-ol moiety


Process Development Objectives
Eliminate hazardous radical reactions Avoid column purification of resolution mixture Improve economics of API route- 12 step synthesis Avoided column chromatography by developing a solid derivative that can be separated by filtration from resolution mixture

Redesigned API route where this expensive chiral piece comes at penultimate step In earlier synthesis it was used in second step-Thus improving economies by several fold Made 500 gm of API with the route which is being used now
Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

New Route & Process Development for a key intermediate for API
Piperidine-4-acetic acid is a key intermediate

Inhibition of Cholesterol Synthesis by Inhibiting Squalene Synthase potent farnesyl protein transferase (FPT) inhibitor
Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

New Route & Process Development


Piperidine-4-acetic acid is a key intermediate Lonarfanib

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Process Development 4-(4-Chloro-pyrimidin-2-ylamino)-benzonitrile for Anti Viral drugs


N N N H N N H
N H N N N N H N

Depivirin (TMC 120)

N N Cl N N H
Br O N HN N NH2 N

Rilpivirine (TMC 278)

Etravirine (TMC 125)


N Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Process Development Synthesis of di-tert-butyl chloromethyl phosphate for The Synthesis of Prodrugs

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Innovative Chemistry
- (+) Lactacystine
Isolated in 1991 by Omura et. Al from Steptomyces sp. First non-protein neurotropic factor Highly useful pharmacological tool Lactone is key active component and acts by acylation of threonine residue

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Innovative Chemistry
Organic synthesis in Aqueous medium
Water as a solvent: 3,4-dihydro-2H-benzo[b]thiazine-3-ones 1,2,3,4-tetrahydro-2-quinoxalinones 2,6-dialkyl-3,5-dicarboxyl-1,4-dihydropyridines & others

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Summary of Chemistry Expertise


Medicinal Chemistry Support New Route Development Process Optimization Innovative Chemistry Reference Standards for Med Chem Support
Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Chemistry Experience Proprietary Building Blocks Developed at CiVentiChem


Global operations in the USA and India with project management, 47 IP control and local solutions at our USA headquarters

Key building blocks for NCEs 7-Azaindoles

Selective, ATP-competitive inhibitors of the mTOR

Selective Inhibitor of Aurora B/C Kinase Active potent VEGFR-2 inhibitor

Selective B-Raf inhibitors

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Key building blocks for NCEs 1H-Indazoles

Potent TRPV1 Antagonist for Pain Management (ABT-102)

Potent and Selective Inhibitors of Factor Xa

Potent CDC7 inhibitors

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Novel 5-HT6 Receptor Antagonists

Azaindoles & (1H)-Indazoles

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Drug Intermediates in Bulk

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Aryl -Keto & Diketo esters

Pyrimidines

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Pyrazole Derivatives

Isoxazole Derivatves

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

2-Naphthol Derivatives (R & S Isomers)

Reagents & Catalysts

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

Facilities
Global operations in the USA and India with project management, 55 IP control and local solutions at our USA headquarters

Facilities - India
Hyderabad, India
Four Synthetic Laboratories
6 Fume hoods in each lab

Analytical Capabilities (HPLC, GC, LC-MS) Provide Competitive Large-Scale Production Provide Chemists (FTEs) Access to Modern Library & Exceptional Scientific Talent from National Labs
Global operations in the USA and India with project management, 56 IP control and local solutions at our USA headquarters

Facilities - India
Plant - Equipment Configuration
Stainless Steel Reactors: 2000 L(1); 1600 L(2); 1000 L(1); 500 L(2); 350 L(4) & 250 L (4) GL Reactors: 2000 L(1); 1000 L(2); 630 L(1) &250 L(1) Autoclave (Hydrogenation) 350 L(1) Yet to be installed and 2.0 L(1) & 0.5 L(1) Auxiliary Filtration, Drying and Milling Separate QC Laboratory and Documentation Center
Global operations in the USA and India with project management, 57 IP control and local solutions at our USA headquarters

Manufacturing Equipment
Production Block
SS316 Reactor SS316 Reactor Glass Lined Reactor SS316 Reactor SS316 Reactor SS316 Reactor SS316 Reactor Glass Lined Reactor Glass Lined Reactor Glass Lined Reactor Glass Lined Reactor Centrifuze SS316 Centrifuze SS316 Centrifuze SS316 Rotocone GL dryer Rotocone SS316 dryer Tray dryer Vacuum Tray dryer Tray dryer Sifter Multi mill Sifter Multi mill Cooling tower Cooling tower Vacuum Pumps 1200L 1000L 1000L 250L 350L 2000L 500L 160L 250L 500L 1600L 36 24" 18" 250 L 50 L 12 trays 6 Tray 24Tray 24 25 Kg/Hr 12 10 Kg/Hr 70 TR 30 TR 300M3/Hr

R&D , Stores and QC


2 No's R&D Labs: 1 No Fume Hoods 27 Nos 1 No Cooling Tower 30TR 2 Nos 2 No's Vacuum Pumps 120M3/Hr 4 Nos 2 No's 1 No Analytical Equipment: 1 No HPLC (Quartanery & Gradient) 2 Nos 2 No's Preparative HPLC, LCMS & GC 1 No Each 1 No 1 No Utility Block 1 No Diesel Generator 180 KVA 1 No 1 No Oil Fired Boiler 1 Ton/Hr 1 No 1 No N2 Generator 99.5 %, 5 m3/h 1 No 1 No 3 DM Plant (with RO) 40 m /Reg 1 No 1 No Air Compressor 70 CFM 1 No 1 No 1 No Corrosive Block 1 No FRP Reactor 2000L 1 No 1 No Glass Lined Reactor 1600 L 1 No 1 No Glass Lined Reactor 630L 1 No 1 No Glass Lined Reactor 100L 1 No 2 No's Hydrogenator -SS316 -350L (25 Kg) 1 No 2 No's Brine Compressor (-20 DEG) 15 TR 1 No 1 No Cooling in tower 165and TR India with project 1 No 1No Global operations the USA management, Centrifuze SS316 & halar coat 36 1 No 4 Nos IP control and local solutions at our USA headquarters

Analytical Facilities CiVentiChem, India


S. No. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Name of the Instrument HPLC With PDA detector HPLC With VWD detector HPLC with PDA Detector Preparative HPLC GC with FID Detector LCMS Analytical Balance Ultrasonicator Digital PH-Meter Microprocessor PH-Meter Conductivity & TDS Meter Melting Range Apparatus Karl Fischer Apparatus Milli-Q Water purification system No. of instruments Make 2 Agilent 1 Agilent 1 Agilent 1 Agilent 2 Agilent 2 Agilent & Schimadzu 2 Denver, Sartorius 2 PCi 2 POLOMON & GLOBAL 1 GLOBAL 1 GLOBAL 2 POLOMON 2 POLOMON 2 Millipore
Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters

For inquiries, please contact: Dr. Venugopal Rao Veeramaneni CiVentiChem India Limited [Formerly known as Indus BioSciences (P) Ltd.,] Plot No. 72/A, Part 2, Phase-I, I.D.A., Jeedimetla, Hyderabad, A.P. , India.. Tel : +91-40-23197766/67/68 Ext: 228; Fax : +91-40-23091692 Mobile: +91-9030026010; e-mail : venu@civentichem.com www.civentichem.com

Global operations in the USA and India with project management, 60 IP control and local solutions at our USA headquarters