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What is Psychosis?
Generic term Break with Reality Symptom, not an illness Caused by a variety of conditions that affect the functioning of the brain. Includes hallucinations, delusions and thought disorder
Mood disorders
Functional disorders
Schizophrenia spectrum disorders
P S Y C H O S I S
Substance induced
SKIZOFRENIA
SKIZOFRENIA
GGN BERAT DLM BIDANG : PIKIRAN, PERASAAN, PERBUATAN, PERSEPSI, KEINGINAN, DORONGAN KEHENDAK & PENGENDALIAN ONSET SULIT DITENTUKAN,BIASANYA DI DAHULUI FASE PRODROMAL (GEJALA RINGAN & TDK KONSISTEN) GEJALA PSIKOLOGIK MAJEMUK : DISTORSI PIKIRAN & PERSEPSI WAHAM & HALUSINASI YG KHAS, AFEK TDK WAJAR / TUMPUL, SIKAP/PERILAKU ANEH, PERASAAN & PIKIRAN DIKETAHUI ORANG ATAU DIKENDALIKAN KEKUATAN GAIB DARI LUAR PERJALANAN PENY SULIT DITENTUKAN, KRONIS, DETERIORASI TERGANTUNG : GENETIK, FISIK & SOSIAL BUDAYA.
Schizophrenia
Schizophrenia occurs with regular frequency nearly everywhere in the world in 1 % of population and begins mainly in young age (mostly around 16 to 25 years).
Schizophrenia is defined by
a group of characteristic positive and negative symptoms deterioration in social, occupational, or interpersonal relationships continuous signs of the disturbance for at least 6 months
History
Emil Kraepelin: This illness develops relatively early in life, and its course is likely deteriorating and chronic; deterioration reminded dementia (Dementia praecox), but was not followed by any organic changes of the brain, detectable at that time. Eugen Bleuler: He renamed Kraepelins dementia praecox as schizophrenia (1911); he recognized the cognitive impairment in this illness, which he named as a splitting of mind. Kurt Schneider: He emphasized the role of psychotic symptoms, as hallucinations, delusions and gave them the privilege of the first rank symptoms even in the concept of the diagnosis of schizophrenia.
4 A (Bleuler)
Bleuler maintained, that for the diagnosis of schizophrenia are most important the following four fundamental symptoms:
affective blunting disturbance of association (fragmented thinking) autism ambivalence (fragmented emotional response)
These groups of symptoms, are called four A s and Bleuler thought, that they are primary for this diagnosis. The other known symptoms, hallucinations, delusions, which are appearing in schizophrenia very often also, he used to call as a secondary symptoms, because they could be seen in any other psychotic disease, which are caused by quite different factors from intoxication to infection or other disease entities.
Course of Illness
Course of schizophrenia:
continuous without temporary improvement episodic with progressive or stable deficit episodic with complete or incomplete remission
3. HALUSINASI PENDENGARAN
a. SUARA BERKOMENTAR TENTANG PERILAKUNYA b. SUARA-SUARA SALING BERBICARA / BERDISKUSI TENTANG HAL IHWALNYA c. SUARA LAIN DARI SALAH SATU BAGIAN TUBUHNYA
4. WAHAM MENETAP LAIN YG MENURUT BUDAYA SETEMPAT DIANGGAP TDK WAJAR / MUSTAHIL
6. ARUS PIKIRAN TERPUTUS ATAU MENGALAMI SISIPAN INKOHERENSI, IRRELEVANSI ATAU NEOLOGISME.
7. PERILAKU KATATONIK : GADUH GELISAH, POSTURING, FLEKSIBILITAS CEREA, NEGATIVISME, MUTISME, STUPOR.
8. GEJALA NEGATIF : APATIS, BICARA JARANG, RESPONS EMOSIONAL YG TUMPUL / TDK WAJAR, PENARIKAN DIRI DARI PERGAULAN SOSIAL, MENURUNNYA KINERJA SOSIAL (BUKAN OLEH DEPRESI ATAU REAKSI NEUROLEPTIKA)
9. SUDAH BERLANGSUNG 1 BULAN (DI LUAR FASE PRODROMAL) 10. PERUBAHAN KONSISTEN BERMAKNA ASPEK PERILAKU HILANGNYA MINAT, HIDUP TAK BERTUJUAN, TDK BERBUAT SESUATU, LARUT DLM DIRI SENDIRI & PENARIKAN DIRI SECARA SOSIAL.
Andreasen N.C., Roy M.-A., Flaum M.: Positive and negative symptoms. In: Schizophrenia, Hirsch S.R. and Weinberger D.R., eds., Blackwell Science, pp. 28-45, 1995
I.
SKIZOFRENIA PARANOID
PALING SERING DITEMUKAN PEDOMAN DIAGNOSTIK
1. PED DIAGNOSTIK UMUM 2. HALUSINASI DAN / ATAU WAHAM HARUS MENONJOL :
a. SUARA MENGANCAM / MEMERINTAH, BUNYI PLUIT, MENDENGUNG ATAU TAWA b. PEMBAUAN / PENGECAP RASA. PERABAAN YG BERSIFAT SEKSUAL, JARANG VISUAL c. WAHAM HAMPIR SETIAP JENIS, TETAPI PALING KHAS ADALAH DIKENDALIKAN, DIPENGARUHI, PASSIVITY DAN DIKEJAR-KEJAR
5.
III.
SKIZOFRENIA KATATONIK
YG MENONJOL GAMBARAN PSIKOMOTOR : HIPEKINESIS, STUPOR, OTOMATISME & NEGATIVISME PEDOMAN DIAGNOSTIK
1. PED DIAGNOSTIK UMUM 2. > 1 PERILAKU MENDOMINASI GAMBARAN KLINISNYA
a. b. c. d. e. f. g. STUPOR ATAU MUTISME GADUH GELISAH POSTURING (TDK WAJAR & ANEH) NEGATIVISME RIGIDITAS FLEKSIBILITAS CEREA GEJALA LAIN : COMMAND AUTOMATISM, VERBIGERASI, EKOLALI & EKOPRAKSI
3.
4.
RAGAM WAHAM EROTOMANIK KEBESARAN (GRANDIOSE) KECEMBURUAN KEJARAN ATAU CURIGA SOMATIK
ONSET : USIA PERTENGAHAN, KADANG DEWASA MUDA (WAHAM SOMATIK)
PED DIAGNOSTIK
1. WAHAM2 MERUPAKAN SATU2NYA CIRI KHAS KLINIS ATAU GEJALA YG PALING MENONJOL, BERSIFAT KHAS PRIBADI & BUKAN BUDAYA SETEMPAT SERTA SUDAH ADA SEDIKITNYA 3 BLN LAMANYA 2. GEJALA DEPRESI MUNGKIN ADA ATAU BAHKAN SUATU EPISODE DEPRESI LENGKAP SECARA INTERMITTEN TETAPI WAHAM MENETAP TERUS ADA PD SAAT2 TDK TERDPT GEJALA AFEKTIF 3. TAK ADA BUKTI TENTANG ADANYA PENYAKIT OTAK ATAU PENGGUNAAN ZAT 4. TAK ADA HALUSINASI DENGAR ATAU HANYA KADANG2 & SIFATNYA SEMENTARA 5. TAK ADA RIWAYAT GEJALA2 SKIZOFRENIA (WAHAM DIKENDALIKAN, SIAR PIKIRAN, PENUMPULAN AFEK, dsb)
BILA ADA WAHAM TAPI < 3 BLN & BKN SKIZOFRENIA ATAU PENYEBAB ORGANIK GGN PSIKOTIK AKUT DGN PREDOMINAN WAHAM.
PEDOMAN DIAGNOSTIK
1. DUA ORANG ATAU LEBIH MENGALAMI WAHAM YG SAMA & SALING MENDUKUNG DLM KEYAKINAN ITU 2. MEREKA MEMPUNYAI HUBUNGAN YG LUAR BIASA DEKATNYA 3. ADA BUKTI DLM KONTEKS WAKTU ATAU LAINNYA BAHWA WAHAM ITU DIINDUKSI MELALUI KONTAK ANTARA ORANG YG DOMINAN DGN YG PASIF
JIKA ADA ALASAN UTK PERCAYA BAHWA DUA ORANG YG TINGGAL BERSAMA MEMPUNYAI GGN PSIKOTIK YG TERPISAH MAKA DIAGNOSIS GGN INI TDK DIBUAT MESKIPUN TERDPT WAHAM YG DIYAKINI BERSAMA. NAMA LAIN : FOLIE A DEUX, GGN PARANOID BERSAMA, PSIKOSIS SIMBIOTIK
PEDOMAN DIAGNOSTIK :
ADANYA CIRI2 UTAMA TERPILIH DARI GGN INI DLM URUTAN PRIORITAS SBB :
1. ONSET AKUT ; DLM JANGKA WAKTU 2 MGG ATAU KURANG, GEJALA2 PSIKOTIK SDH NYATA & MENGGANGGU SEDIKITNYA BBRP ASPEK KEHIDUPAN & PEKERJAAN SEHARI2. 2. ADA SINDROM KHAS BERUPA POLIMORFIK ARTINYA ADA ANEKA RAGAM GEJALA & BERUBAH CEPAT ATAU GEJALA SKIZOFRENIA YG KHAS. 3. ADA STRES AKUT TERKAIT, NAMUN TAK PERLU SELALU ADA
TDK MEMENUHI KRITERIA EPISODE MANIK ATAU DEPRESIF, WALAUPUN PERUBAHAN EMOSIONAL & GEJALA2 AFEKTIF DPT MENONJOL DARI WAKTU KE WAKTU. TDK ADA PENYEBAB ORGANIK ATAU INTOKSIKASI AKIBAT PENGGUNAAN ZAT.
I.
PEDOMAN DIAGNOSTIK
1. PEDOMAN DIAGNOSTIK UMUM 2. HALUSINASI ATAU WAHAM YG BERUBAH DLM JENIS & INTENSITASNYA 3. KEKALUTAN EMOSIONAL YG ANEKA RAGAM & LEBIH SERING SENANG, SEDIH, CEMAS ATAU MARAH 4. GEJALA YG ANEKA RAGAM ITU TAK SATUPUN SECARA CUKUP KONSISTEN DPT MEMENUHI KRITERIA SKIZOFRENIA, EPISODE MANIK ATAU DEPRESIF
IV.
UNTUK D/ PASTI:
ONSET GEJALA PSIKOTIK HRS AKUT WAHAM & HALUSINASI HRS SUDAH ADA DLM SEBAGIAN BESAR WKT SEJAK BERKEMBANGNYA KEADAAN PSIKOTIK YG JELAS TDK MEMENUHI KRITERIA SKIZOFRENIA MAUPUN PSIKOTIK POLIMORFIK AKUT
KALAU WAHAM MENETAP > 3 BLN GGN WAHAM MENETAP, KALAU HALUSINASI MENETAP > 3 BLN GGN PSKOTIK NONORGANIK LAINNYA
Genetics of Schizophrenia
Many psychiatric disorders are multifactorial (caused by the interaction of external and genetic factors) and from the genetic point of view very often polygenically determined. Relative risk for schizophrenia is around:
1% for normal population 5.6% for parents 10.1% for siblings 12.8% for children
Etiology of Schizophrenia
The etiology and pathogenesis of schizophrenia is not known It is accepted, that schizophrenia is the group of schizophrenias which origin is multifactorial:
internal factors genetic, inborn, biochemical external factors trauma, infection of CNS, stress
Classical dopamine hypothesis of schizophrenia: Psychotic symptoms are related to dopaminergic hyperactivity in the brain. Hyperactivity of dopaminergic systems during schizophrenia is result of increased sensitivity and density of dopamine D2 receptors in the different parts of the brain.
Treatment of Schizophrenia
The acute psychotic schizophrenic patients will respond usually to antipsychotic medication. According to current consensus we use in the first line therapy the newer atypical antipsychotics, because their use is not complicated by appearance of extrapyramidal side-effects, or these are much lower than with classical antipsychotics.
conventional antipsychotics (classical neuroleptics) atypical antipsychotics
Psychosocial Factors
Expressed emotion Stressful life events Low socioeconomic class Limited social network
Typical Neuroleptics
Low potency:
Chlorpromazine Thioridazine Mesoridazine
High potency:
Haloperidol Fluphenazine Thiothixene Loxapine (mid)
Atypical Antipsychotics:
Risperidone Olanzapine Quetiapine Clozapine Ziprasidone Aripiprazole (new-partial DA agonist)
Atypical Antipsychotics:
Risperidone Olanzapine Quetiapine Clozapine Ziprasidone Aripiprazole (new-partial DA agonist)
Treatment
May require admission if acutely disturbed or present a risk to self or others Admission may be useful in assessment Essential to assess suicide risk as there is a mortality of about 10% from suicide in SCZ May require involuntary detention in some cases
Treatment contd.
Antipsychotic drugs are mainstay of treatment Generally atypicals are first-line treatment eg olanzapine, respiridone, amisulpiride May require depot injection Side effects of typicals can be stigmatising Side effects of atypicals screen for DM
Treatment contd.
Atypicals have fewer extra-pyramidal side effects and tend to be better for negative symptoms that typicals Initial management may include use of sedative medication such as lorazepam IM medication may be required in a very disturbed, involuntary patient
Treatment contd.
Maintenance treatment generally maintenance on one medication Compliance may be a significant problem because of long-term nature of treatment and lack of insight
Treatment contd.
Psychosocial treatment
Education of patient and carers Reduction of high expressed emotion shown to affect relapse rates Cognitive behavioural therapy controversial Rehabilitation Self help Schizophrenia Ireland
Prognosis
22% have one episode and no residual impairment 35% have recurrent episodes and no residual impairment 8% have recurrent epsiodes and develop significant non-progressive impairment 35% have recurrent episodes and develop significant progressive impairment
Prognosis contd.
The majority therefore do not recover fully Suicide rate is up to 13% Little evidence that anitpsychotic have altered the course of illness for most patients However, evidence that prolonged psychosis which is untreated has a bad prognosis
Prognosis contd.
Good outcome is associated with:
Female Older age of onset Married Higher SEG Living in a developing (as opposed to developed) country Good premorbid personality No previous psych history Good education and employment record Acute onset, affective symptoms, good compliance with meds
Prognosis contd.
Some of the predictors of outcome are the consequence of a less severe illness Predicting risk of suicide
Acute exacerbation of psychosis Depressive symptoms History of attempted suicide