Biological activity Corticosteroid Mineralocorticoid Aldosterone promote Na+ reabsorption at distal conv.

v. Tbl excretion of K+ & H+ Addisons disease adrenal insufficiency Na+excreation

Glucocorticoid cortisol Antianabolic & catabolic contra insulin

Antiinflamatory Sex hormone development, growth, maintenance & regulation of reproductive system androgen C19 estrigen C18 Progresterone Androgen produced by testis testosterone 5-dihydrotestosterone (DHT) active form

 Regulated by FSH & LH stimulate the production of ABP in Sertoli CSCC in P450 transported by TeBG metaboliszed in liver excreted via kidney as sulfates 7 glucoronides

Estrogens produced by : --ovary (E2 - estradiol & E1 - estrone) --placenta (E2, E1 & E3 - Estriol) activity similar with androgen: increase lipogenesis (TAG/, Chol/, HDL/, LDL/) increase protein synthesis in the liver (transcortin, ceruloplasmin, CBG, TBG) decrease clotting time increase platelet aggregation regulated by FSH & LH
Progesterone internediate in all steroid secreting cells produced by CL & placenta bound to transcortin (CBG) affinity to CBG > cortisol metabolized to pregnandiol glucoronide

Cell

Lymphocyte

Skeletal muscle

Bone Protein synthesis Enzyme induction Aminotranferases F-1, 6-bisPase G-6 Pase Gluconeogenesis Glucose Glycogen

Cell Lysis

Catabolic activity

Blood

Amino acids

Amino acids Cell K+ and Ca2 + ions

Urine

Nitrogen excretion (glucose) Electrolytes, water

Muscle Cell

(+)
Amino acids Muscle Cell (+) (-) Glucose (+) Amino acids Protein (-)

Glucose

Glycogen and Metabolism

Inflammmatory response
Production of PlateletNitric Activating oxide factor Phosphatidyl choline Phospholipase Arachidonic acid Cyclooxygenase Lipooxygenase

Immune response
Macrophage Antigen

Interleukin-1

Fever

T cells

Prostaglandins Thromboxanes

Leukotrienes

Interleukin2 and 6

Tumor necrosis factor

Neutrophil function Vasodilation

T-cell proliferation

Phagocytosis
Permeability Leukocyte trapping Bacterial killing B-cell proliferation

Antibody production

7-Dehydro cholesterol Activated in the Skin by sunlight

Ring opening And hydroxylations

Liver Kidney 1, 25 - dihydroxy vitamin D3 Bone Intestine

Binding of active Metabolite to Vitamin D3 receptor

Ca2+ Binding Protein induced

Mineralization

Absorption of Ca, Pi
Reabsorption of Ca, Pi

Plasma calcium

PTH secretion
Plasma phosphate Renal phosphate 1,25 - (OH)2-D3 Urine calcium Intestinal absorption + Bone resorption Plasma calcium Plasma phosphate

Urine phosphate

PTH secretion
1,25 - (OH)2-D3 24,25 - (OH)2-D3

If excessive Calcitonin secretion

Plasma phosphate Renal phosphate

1,25 - (OH)2-D3 Intestinal absorption + Bone resorption Plasma phosphate 1,25 - (OH)2-D3

Plasma calcium PTH secretion Urine phosphate Urine calcium

24,25 - (OH)2-D3