Beruflich Dokumente
Kultur Dokumente
Concept 5.1
Polymer: a long molecule consisting of similar or identical building blocks - like a train with many cars - monomers: repeating units that are the building blocks Diversity of life is based around 40 or 50 polymers
Concept 5.1
Monomers are connected together by dehydration synthesis (anabolic) - covalent bond w/ the loss of H2O Polymers are broken down by hydrolysis (catabolic) - reverse rxn. of dehydration synthesis - break with water
Concept 5.1
HO 1 2 3 H HO H
Short polymer Dehydration removes a water molecule, forming a new bond Unlinked monomer H2O
HO
(a)
Concept 5.1
HO 1 2 3 4 H
H2O
HO
HO
Concept 5.2
Carbohydrates: include sugars and polymers Monosaccharides (monos = single; sacchar = sugar) - molecular formula is CH2O - ex. Glucose (C6H12O6) - most sugars are rings when aqueous
Concept 5.2
Concept 5.2
Disaccharide: two monosaccharides joined by a glycosidic linkage - formed by dehydration synthesis - glucose + glucose = maltose + H2O - glucose + fructose = sucrose + H2O
Concept 5.2
Glucose
Glucose
Maltose
Glucose
Fructose
Sucrose
Concept 5.2
Polysaccharides: polymers w/ few hundred to a few thousand monomers -fcn. of a polysaccharide is determined by monomers and positions of glycosidic linkages
Concept 5.2
Storage polysaccharides - starch: found in plants; consists only of glucose monomers (1-4 linkage); how plants store glucose (chloroplasts) - glycogen: polymer of glucose found in animals; stored in liver and muscle cells
Concept 5.2
Structural polysaccharides - cellulose: major component of plant cell walls - note: 2 ring structures of glucose (alpha (a) and beta (b)) - cellulose is composed of all b glucose - cellulose = insoluble fiber
Concept 5.2
b Glucose
Concept 5.2
Concept 5.2
Cell walls Cellulose microfibrils in a plant cell wall Microfibril
10 m 0.5 m
Cellulose molecules
b Glucose monomer
Carbohydrates
Structural polysaccharides (cntd.) - chitin: carbohydrate used by arthropods to build exoskeletons - also used to make decomposable surgical thread
Concept 5.2
Concept 5.3
Lipids: little or no affinity for water; consist mostly of hydrocarbons - 3 families: fats, phospholipids, steroids
Fat: composed of 2 parts - glycerol: 3 carbon alcohol w/ hydroxyl - fatty acids: long carbon skeletons w/ carboxyl groups
Concept 5.3
Fatty acid (palmitic acid) Glycerol (a) Dehydration reaction in the synthesis of a fat
Concept 5.3
Fatty acids can vary in length and in the number and location of double bonds - saturated: no double bonds; most animal fats; solid at room temp. - unsaturated: has one or more double bonds which removes H atoms; plants and fish; liquid at room temp.
Concept 5.3
Structural formula of a saturated fat molecule Stearic acid, a saturated fatty acid (a) Saturated fat
Concept 5.3
Concept 5.3
The major fcn. of fats is energy storage. - 1g of fat stores more than twice as much energy as 1g of a polysaccharide - mammals stock food reserves in adipose cells
Concept 5.3
Phospholipids: similar to fats but have only 2 fatty acid tails; 3rd hydroxyl group joins to a phosphate group - show ambivalent behavior to water - head= polar (hydrophilic); tail= nonpolar (hydrophobic) - arranged in a bilayer, or double layer
Concept 5.3
Hydrophobic tails Hydrophilic head Choline Phosphate Glycerol
Fatty acids
Hydrophilic head
Hydrophobic tails (b) Space-filling model (c) Phospholipid symbol
Concept 5.3
Steroids: lipids with a carbon skeleton consisting of 4 fused rings - differ in functional groups attached to rings - Cholesterol: found in animal cell membranes; precursor for other steroids
Concept 5.3
Concept 5.4
Proteins: account for more than 50% of the dry weight of most cells - used for structural support, storage, transport, signaling, movement, and defense
Concept 5.4
Proteins are polymers constructed from the same set of 20 amino acids - called polypeptides - consist of one or more polypeptides folded and coiled into specific conformations
Concept 5.4
Amino acids are the building blocks of proteins - a carbon is bonded to an animo group, a carboxyl group, a hydrogen atom, and a variable (R) - grouped according to side chains (nonpolar, polar, acidic, basic)
Concept 5.4
Concept 5.4
Concept 5.4
Amino acids are bonded together by a peptide bond - carboxyl group of one amino acid connects w/ the amino group of another (dehydration synthesis)
Concept 5.4
Concept 5.4
Four levels of protein structure - primary structure: unique sequence of amino acids - even a slight change can affect a proteins conformation and ability to function - ex. Sickle-cell disease
Concept 5.4
Concept 5.4
- secondary structure: coils or folds that are a result of hydrogen bonds at regular intervals - a helix: delicate coil held together by hydrogen bonding between every fourth amino acid - b pleated sheets: two or more regions lie parallel to each other
Concept 5.4
Concept 5.4
- tertiary structure: irregular contortions from interactions between side chains (R groups) - hydrophobic interactions: nonpolar side chains cluster in the core, away from water - van der Waals interactions help hold them together
Concept 5.4
- disulfide bridges: covalent bond between two cysteine monomers (have sulfhydryl groups) - ionic bonds and hydrogen bonds also contribute
Concept 5.4
Concept 5.4
- quaternary structure: overall protein structure resulting from combining of multiple subunits The unique conformation endows each protein with a specific function
Concept 5.4
Concept 5.4
Concept 5.4
The unique conformation endows each protein with a specific function - denaturation: protein unravels and losses its conformation - pH, [salt], temperature
Concept 5.5
Compounds that are responsible for determining the amino acid sequence of a polypeptide. Two types of nucleic acids - deoxyribonucleic acid (DNA) - ribonucleic acid (RNA) Flow of genetic information: DNA RNA Protein
Concept 5.5
DNA 1 Synthesis of mRNA in the nucleus NUCLEUS CYTOPLASM mRNA 2 Movement of mRNA into cytoplasm via nuclear pore 3 Synthesis of protein Polypeptide Amino acids Ribosome mRNA
Concept 5.5
Nucleotides are the monomers (building blocks) of nucleic acids -nucleotide = nitrogenous base + pentose (5-carbon sugar) + phosphate
Concept 5.5
5 end 5C 3C Nitrogenous bases
Pyrimidines
Nucleoside
Nitrogenous base Uracil (U, in RNA) Cytosine (C) Thymine (T, in DNA) Purines
5C 3C 3 end
Phosphate group
(b) Nucleotide
Concept 5.5
Two families of nitrogenous bases: - pyrimidines: single ring; cytosine (C), thymine (T), and Uracil (U) - purines: double ring; adenine (A), and guanine (G)
Concept 5.5
Difference between DNA and RNA is in the sugar. DNA lacks an oxygen atom attached to its number 2 carbon Polynucleotide: nucleotides are joined by phosphodiester linkage
Concept 5.5
DNA molecules have two polynucleotides that form a double helix. - Watson and Crick (1953) - A binds to T; C binds to G; forms two complementary strands