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Dairion Gatot Divisi Hematology -Onkology Medic Internal Departement of Medical Faculty of North Sumatera University / Haji Adam Malik General Hospital, Medan 2010
Definition
Tumor Neoplasma
Benigna
Maligna
cancer
( = cancer = lobster)
Group of diseases Progressif and uncontrol (abnormal) development to be enlargement tumor (Neoplasma) Tumor benigna and malignant. Benigna tumor : abnormal development, is not spread. Malignan tumor : abnormal development, spread, metastase. Tumor solid = hard cancer, Tumor non solid = liquid cancer
Mitosis/miosis activity
computer Program
DNA
Analysis Data
Instruction Program
Printer output
PATOGENSIS OF CANCER ?
Etiology
Radiation
Gen damage
Normal cel
DNA
CANCER CHARACTERISTIC ?
Cancer vs Normal
Progressif, uncontrol. Metastatic stadium IV Non infectious Herediter (?) Genetik !
Cancer vs Normal
Cancer : Uncontrol development and proliferation Immortal To presure normal cell
2-6 week
Cancer Cell size : One milyar cancer cell = nail spuit One billion cancer cell =strowberry 230 = 1,073,741,824 = 1 milyar cell
2-6 week
METASTASIS CANCER ?
Stadium / tahap
Karsinoma (cancer
surface area)
Leukemia Limfoma
Lung
Breast
Colon
CANCER DIAGNOSTIC
CLINIS (STAGING)
CYITOLOGIS / HISTOPHATOLOGY
RADIOGRAFI
ONCOMARKER
IMUNOHISTOCHEMISTY
HEMATOLOGY MALIGNACY
INTRODUCTION
Malignancy Hematology :
From single cel , bone marrow, thymus or lymphoid perifer system. - Cel , genetic mutation malignant transformation malignant cel. - Excessive mitosis and uncontrol clone malignant cel. And or resisten for Apoptosis
Classification :
Characteristic malignancy hematology and lymphoid : 3 Characteristic : Aggressiveness: Acute versus Chronic Lineage: Lymphoid versus Myeloid
De Vita
EBM
Criteria for Remission in Acute Leukemia Hematologic Complete Response: BM Aspirasi : Normal cellularity dan < 5% Blast dari semua cell berinti Darah Tepi : Tanpa cell lekemia dan Lekosit > 3000/mm3 Granulosit > 1500/mm3 Trombosit > 100.000/mm3 Lain lain : tak ada tanda klinik lekemia LUMC