Sie sind auf Seite 1von 8
 
 
The Multi-step Model of Leukocyte -Endothelial Interactions
LeukocyteLeukocyte in flow in flow 
(1a) Tethering(1a) Tethering
BloodBlood
(1b) Rolling(1b) Rolling(3) Firm adhesion(3) Firm adhesion
LeukocyteLeukocyte in tissuein tissue
(4) Transmigration(4) TransmigrationChemotaxisChemotaxis
FLOW FLOW 
(2) Activation(2) Activation
Inflamed TissueInflamed Tissue
 
 
Seeding
 
BM Matrix
Hematopoietic Cell Engraftment in Bone Marrow
Endothelial cells
 
 
Homing” of HSCsHoming” of HSCs
Bone marrow - identifiable by the fat cells, clusters of Bone marrow - identifiable by the fat cells, clusters of developing blood cells, and the large megakaryocytes. developing blood cells, and the large megakaryocytes. Also, in the middle of the field is aAlso, in the middle of the field is a cross section of a cross section of a sinusoid filled with rbc's.sinusoid filled with rbc's. Sinusoid of bone marrow seen here in longitudinal Sinusoid of bone marrow seen here in longitudinal section. There is a nucleus of a lining endothelial cell section. There is a nucleus of a lining endothelial cell near the lower center of the field. Junctions between near the lower center of the field. Junctions between endothelial cells are loose so that HSCs can enter and endothelial cells are loose so that HSCs can enter and exit the blood vessels.exit the blood vessels.

Ihre Neugier belohnen

Alles, was Sie lesen wollen.
Jederzeit. Überall. Auf jedem Gerät.
Keine Verpflichtung. Jederzeit kündbar.
576648e32a3d8b82ca71961b7a986505