Alesa 2.

5 / 5 gel
Alesa 2.5 gel Clindamycin 1% Benzoyl peroxide 2.5% Alesa 5 gel Clindamycin 1% Benzoyl peroxide 5 Availability 1 sachet
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 A Additive Bactericidal with Antiinflammatory action.

L Least Bacterial Resistance E Efficacious for Inflammatory Acne S Speedy onset of action A Accuracy of dosing
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Alesa Gel
Combination gel have demonstrated efficacy through different mechanisms of action in treatment of acne vulgaris.
Both drugs have an antibacterial effect, anti-inflammatory properties through different means
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Alesa Gel
Benzoyl peroxide has a mild keratolytic effect which results in desquamation and comedolysis Benzoyl peroxide because of its lipophilicity is able to easily enter and concentrate in lipid-rich pilosebaceous units. Moreover, the combination of benzoyl peroxide and clindamycin has been shown to reduce antibacterial resistance of P. acnes.
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Alesa Gel
Antibacterial Properties
Clindamycin Phosphate Benzoyl peroxide: Through interaction of the Clindamycin is oxidized intermediates of bacteriostatic, benzoyl peroxide with (bactericidal depending elements of the bacterial cell. on bacterial susceptibility & concentration of drug at Rapid & greater effect in suppressing P acne site of infection) compared with topical antibiotic. Inhibits protein No evidence of P acne synthesis resistance to BP
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Alesa gel
Anti-Inflammatory Properties Clindamycin: Topically applied clindamycin directly reduce inflammation in acne lesions by methods other than through reduction of P. acnes counts When PMNs arrive at comedo, lysosomal hydrolytic enzymes are secreted which may contribute to rupture of follicular duct. Clindamycin has been shown to significantly suppress complement-derived chemotaxis of PMNs with minimal effect on their random migration.

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Alesa gel
Anti-Inflammatory Properties Benzoyl peroxide: Antibacterial, mildly comedolytic, and sebostatic agent. It reduces number of inflammatory lesions of acne Main effect through bactericidal means Weak anti-inflammatory properties PMNs migrate to site of inflammation following release of chemotactic factors by both P. acnes & host. PMNs subsequently phagocytize bacteria, during which process, oxygen is consumed and tissue-toxic reactive oxygen species (ROS) are released enhancing inflammatory damage.

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Alesa gel
Anti-Inflammatory Properties Benzoyl peroxide:
Benzoyl peroxide dose-dependently inhibit release of ROS from PMNs This inhibition elicited through druginduced killing of PMNs

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Alesa gel
Indications
indicated in treatment of severe inflammatory acne Dosage and Administration Apply to affected areas once or twice daily after washing with a mild soap, rinsing & patting skin dry
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Alesa gel : Competition

Indirect : [Clindamycin] Clindac A, Solution & gel (Galderma) Crixan gel (Crosslands) Clear gel (H & H) [Benzoyl peroxide] Benzac AC (Galderma)

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