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Minerals
The elements essential for life , can be divided into macro elements (daily requirement > 100 mg) and microelements (daily requirement < 100 mg). The macroelements include the electrolytes sodium (Na), potassium (K), calcium (Ca), and magnesium (Mg), and the nonmetals chlorine (Cl), phosphorus (P), sulfur (S), and iodine (I)..
molybdenum (Mo). Fluorine (F) is not essential for life, but does promote healthy bones and teeth. It is still a matter of controversy whether vanadium, nickel, tin, boron, and silicon also belong to the essential trace elements .
Minerals stored in the body include water, which is distributed throughout the whole body; calcium, stored in the form of apatite in the bones ; iodine, stored as
Mineral deficiencies
An unbalanced diet, resorption disturbances, and diseases. Calcium deficiency can lead to rickets,
osteoporosis, and other disturbances. Chloride deficiency is observed as a result of severe Cl losses due to vomiting. Due to the low content of iodine in food in many regions of central Europe, iodine deficiency is widespread there and
Magnesium
deficiency
can
be
inorganic ions
(Na) and potassium (K), and the alkaline earth metal smagnesium (Mg) and calcium(Ca). The halogen chlorine (Cl) is also always ionized in the cell. All other elements
Iron metabolism
Distribution of iron (Fe) is quantitatively the most
important trace element . The human body contains 45g iron, whichis almost exclusively present in protein-bound form. Approximately three-quarters of the total amount is found in heme proteins , mainly hemoglobin and myoglobin. About 1% of the iron is bound in ironsulfur clusters , which function as cofactors in the respiratory
ions are almost completely resorbed from the primary urine by active
transport (i.e., in an ATP-dependent fashion). The proportion of Ca2+ resorbed is over 99%, while for phosphate is 8090%. The extent to which these two electrolytes are resorbed is regulated by the three hormones parathyrin, calcitonin, and calcitriol.
extracellular
proteins,
particularly collagens, and mineral substances, which they use to build up the extracellular matrix . By contrast, osteoclasts dissolve bone matter again by secreting H+ and collagenases
Calcium metabolism
A.Functions of calcium
The human body contains 11.5 kg Ca2+, most of which (about 98%) is located in the
a signaling substance .
Ca2+ ions act as second messengers in signal transduction pathways , they trigger exocytosis and muscle contraction , and they are indispensable as cofactors in
Calcitriol levels
increases
blood
Ca2+ Ca2+
through
increased
precursor of calcitriol, can therefore have unfavorable effects on the skeleton similar to those of vitamin deficiency
(hypervitaminosis).
Calcium homeostasis
Ca2+metabolismis balanced in healthy adults. Approximately 1g Ca2+ is taken up per day, about 300 mg of which is resorbed. The