Development of Collagen

Based Drug Delivery Systems

Ivy Kanungo
Chemical Lab
Presentation Outline
Background Information

Drug Delivery Systems

Biomaterials

Collagen

Current Drug Delivery Systems

Problems Associated with Collagen based Drug Delivery

Aim and Objective

Design Constraints

Plan of Work
 Drug Delivery

Drug delivery is the method or process of

administering a pharmaceutical compound to achieve a
therapeutic effect in humans
Routes of Drug Administration
Intestinal Rectal
Intravenous/ Nasal

Intraarterial Pulmonary

Intramuscular/ Vaginal


Subcutaneous Intrauterine

Oral Transdermal

Ocular
Buccal / Sublingual
Methods of Drug Delivery

5
Ideal Drug Delivery System
Release rate dictated by the needs of the body

over the period of treatment

Constant, 0-order (clear PK PD)

Channel the drug to the active site, cell, tissue,

organ (drug targeting)

“No such DDS exists which combines ABOVE …!!!”

Improved drug delivery
Continuous maintenance of drug include
levels in

therapeutically desirable range

Potentially decreased amount of drug needed

Decreased amount of dosage and possibly less

invasive dosing

Reduction of harmful side effects due to

targeted delivery to a particular site

Controlled Delivery Attempts
Sustain drug action at a predetermined rate by
maintaining a relatively constant, effective drug
level in the body with concomitant minimization of
undesirable side effects associated with a sawtooth
kinetic pattern

Localize drug action by spatial placement of a

controlled release system (usually rate controlled)
adjacent to or in the diseased tissue or organ
Target drug action by using carriers to

deliver drugs to a particular “target” cell

type
Targeted Drug Delivery
Drug Release Profile
Plasma drug concentration-

profiles for conventional

Concentration

tablet or capsule formulation,

a sustained release

formulation, and a zero-

order controlled release

formulation
Physicochemical Properties of a Drug
Influencing Design and Performance
Solubility

Molecular weight

Chemical stability

Physical stability

Protein binding capability

Biological Characteristics of a Drug
Influencing Design and Performance
Duration of action

Safety

Side effects

Margin of safety

Role of disease state

Biomaterials
BioCompatibilty

Biodegradability

Issues to consider:

Viability

Placement
Factors Influencing the Selection of
the Carrier Material
Size of the carrier required

Inherent properties of the drugs i.e. aqueous solubility or

stability

Surface characteristics i.e. charge and permeability

Degree of biocompatibility, biodegradability and toxicity

Drug release profile required

Routes of application of drugs

Antigenicity of the final product

 Aim
Development of collagen based targeted drug

delivery for sustained release

 Objective
Chemical modification of collagen without

affecting its triple helical conformation

Development of drug entrapped collagen

based biomaterials for sustained release

profile
Collagen: Fibrous Protein

Stabilizing
Inter-strand
H-bonds

Gly-Pro-HyPro Repeat
A three dimensional structure which works as a

natural distance barrier between the drug is

incorporated into the matrix and the surroundings

environment

A network which enhances cell penetration and new

tissue generation
Adjustable bio degradability and bio
resorbability by cross linking

Good resistance and tensile properties

Compatible with synthetic polymers

High water absorbability

Partial open porosity

Partial close porosity

Tertiary release of the drugs

Collagen based drug delivery
Sponge or Film

Hydrogel mediated drug delivery

Colloidal drug delivery

Limitations
Sponge or film can be used for the treatment of

the incision of the outer part of the body

The quantity and homogeneity of drug loading into

hydrogels

Colloidal based delivery system faces dispersion

and stability problem because of their strong

cohesiveness and high surface areas

Design Constraints
Better Drug entrapment

Targeted delivery

Inexpensive

Sterile

Biocompatible

Sustained Delivery Profile

Scaled up
Goal: Design Autonomous Nano
Medical Systems
Definition: Self-guiding, adaptive, multicomponent

systems on the nanoscale for diagnostic and therapeutic

prevention or treatment of disease

Value: “smart” nanomedical systems can deal with

changing conditions, are error-correcting, and can

provide proper dose of therapeutic response on a cell-

by-cell basis
Why nanoparticles are desired
for drug delivery system?
 ? ?
?? ?

?
Questions?
Concept: Smart Targeted, Programmed Sequence
of Events, Nanomedicine Systems with Biomolecular
Sensors for Control of Gene/Drug Delivery within Single
Cells Y Y Y Cell targeting and
Y entry
Y Y Y Y Intracellular
Y Y Y targeting
Y Y

Biomolecular
Y Y Y Y

sensing

Y
Y
Gene/drug delivery
Y

Biomolecular sensors
Y
Y
Y

Y
Y
Y
Y

Y
Y Y

Y
Y Y
Y
Y

Y Y
Y Y Y
Challenges: Optimal Drug Delivery
to the Single Cell
Changing of collagen struture and shape without

affecting its amino acids sequences

Use and selection of crosslinking agent

Loading of drugs

Potential Solution: Delivery of a drug manufacturing

(in-situ) factory, not a drug

The Future

…….is full of

surprises and

unintended

consequences