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and Cortisol
Renz Jethro M. Ortega III BS in Medical Technology Emilio Aguinaldo College Manila
Objectives
De ine the adrenal gland Di!cu!! the anatomy and "hy!iology o adrenal gland Identi y the hormone! and location! they are "roduced in the adrenal gland E#"lain corte# !teroidogene!i! and $io!ynthe!i! o catecholamine E#"lain the hormone corti!ol
Adrenal Gland
A multi unctional endocrine organ that "roduce! !teroid hormone! and neuro"e"tide! e!!ential or li e. Su"rarenal gland% ound ato" the &idney!. A "yramidal !tructure 'eighing a""ro#. ( gram!.
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Right !u"rarenal *ein drain! into the in erior *ena ca*a. :e t !u"rarenal *ein drain! into the le t renal canal o the le t "hrenic *ein.
Clinical Chemistry @Michael :. Bi!ho" MS MT <ASCA> C:S <BCA>) Ed'ard A. /ody MD) :arry E. Schoe MS MT <ASCA>C Dth edition
"ona Glomerulosa
Synthe!ize aldo!terone <mineralocorticoid!>. Critical or !odium retention <*olume>) "ota!!ium and acidE$a!e $alance. =a*e lo' cyto"la!micEtoEnuclear ratio and !mall nuclei 'ith den!e chromatin 'ith intermediate li"id inclu!ion!. 2 cell! con*ert chole!terol to "regnenolone.
"ona Fasciculata
Synthe!ize glucocorticoid! !uch a! corti!ol and corti!one) critical or $lood gluco!e homeo!ta!i! and $lood "re!!ure. Cord! o clear cell!) 'ith high cyto"la!micE toEnuclear ratio and li"id! laden 'ith oamy cyto"la!m. 2enerate androgen "recur!or D=EA <dehydroe"iandro!terone>
"ona #eticularis
Sul ate D=EA to D=EAS) the main adrenal androgen. Andro!tenedione and dehydroe"iandro!terone Shar"ly demarcated 'ith li"idEde icient cord! o irregular) den!e cell! 'ith li"o u!cin de"o!it!.
Cortex Steroido!enesis
Bio!ynthe!i! o hormone! occur *ia !u$!trate a*aila$ility) enzyme acti*itie! and inhi$itory eed$ac& loo"!.
Stored LDL Use Acetyl-CoA Cortisol Primary !eedbac" #egulator$
Clinical Chemistry @Michael :. Bi!ho" MS MT <ASCA> C:S <BCA>) Ed'ard A. /ody MD) :arry E. Schoe MS MT <ASCA>C Dth edition
/ 0 % /pinephrine ./ % .orepinephrine
Clinical Chemistry @Michael :. Bi!ho" MS MT <ASCA> C:S <BCA>) Ed'ard A. /ody MD) :arry E. Schoe MS MT <ASCA>C Dth edition
Cortisol
A glucocorticoid "roduced $y zona a!ciculata o the adrenal corte#. Main unction i! to control hemodynamic! <$lood "re!!ure> and gluco!e homeo!ta!i! <antiEin!ulin e ect>. Regulated $y ACT=% only hormone inhi$iting ACT= Diurnal% high le*el! in morning <DEF am> and lo'e!t at night <84 "mE87 am> 345 in inacti*e and $ound to "rotein <tran!cortin> Re erence *alue- FE8G mg.d:
#eferences5
Clinical Chemistry @Michael :. Bi!ho" MS MT <ASCA> C:S <BCA>) Ed'ard A. /ody MD) :arry E. Schoe MS MT <ASCA>C 6th edition #evie7er for Clinical Chemistry @Maria Tere!a RodriguezC 8nd edition $enry9s Clinical (ia!nosis and Mana!ement by )aboratory Methods @Richard A. McAher!on) MD and Matthe' R. Aincu!) MD) AhDC 88nd /dition htt"-..'''.ouh!c.edu.hi!tology.2la!! 574!lide!.93049.1"g
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