O-BUSTERS &Humidity Indicating Cards

NIRZARI

O-Busters
These sachets are specially designed so as to absorb the moisture in a packed environment bringing down the oxygen level to almost 0%. The material of construction of the sachets is a three layer arrangement comprising of PET/PAPER/PE. Material inside the sachets is Iron powder, Natural Zeolite, Salt & water. Comes in varied sizes. Sizes range from FT-20cc to FT-3000cc. The name FT-20cc, FT-50cc etc indicate the absorbing capacity of these sachets. It has its presence in many industries, we would now discuss its application in Pharmaceutical & Food industries.

Pharmaceutical industry
After hydrolytic degradation, oxidative degradation is one of the most common modes of degradation addressed by formulators to protect a drug. In contrast to hydrolysis, oxidative mechanisms are complex and often trigger irreversible degradation of the drug compound once initiated. Oxygen is a well-known source of degradation in many types of pharmaceuticals. When drugs are packaged, oxygen that was trapped in the container headspace during the filling process or that enters the container from the outer atmosphere during shelf storage can cause adverse effects, most critically molecular changes leading to loss of potency. Pharmaceutical industry directly reflects on the human life and so all the products related to it are scrutinized carefully before any application.

These O-busters have proved marvelous in the Pharmaceutical industry to protect the drugs that are sensitive to oxygen. Some of these Drugs are Atorvastatin, Asenapine, Prasugrel, Tapentaddol, Parentropil, Fluvastatin, Ethacrynate Sodium and many more. These drugs are proved to be highly oxygen sensitive and so the use of O-Busters along with these increase the shelf life of the same. Due to the varied sizes, these sachets can be used for formulations in bottles as well as in HDPE Drums, LDPE Bags, Containers for API. O-Busters eliminate the need to Nitrogen flushing.

Recently, however, the need for effective oxygen absorption solutions has been intensified by three trends:

1. The

demand for increased shelf life allowing for cost optimization in drug manufacturing and distribution. 2. A higher proportion of molecules in the drug pipeline in Classes II and IV. These classes of molecules are often formulated with new galenic forms, which make them more sensitive to oxygen. 3. Potentially greater scrutiny by the U.S. Food and Drug Administration (FDA) regarding maintenance of potency to the end of shelf life.

How Oxygen affects drugs

Oxygen induces drug degradation Chemical hydrolysis of drug Discoloration of product Harmful reactivity with active compound Dissolution of disintegrates Efficacy of drug is lowered Growth of aerobic micro-organisms

How to use the O-Busters?

O-Busters chemically react with oxygen and to remove it from the packing area in question. These sachets are very reactive and start their action once exposed to air, this process releases some heat, this heat is minor when talking about one sachet but when these sachets are stacked on top of one another the heat increases and the reaction is fastened. So as to prevent this, spread the sachets in a tray so that they dont touch each other, and then start the insertion process for best results.

Food Industry
Many foods are very sensitive for oxygen, which is responsible for the deterioration of many products either directly or indirectly. In fact, in many cases food deterioration is caused by oxidation reactions or by the presence of spoilage aerobic microorganisms. Therefore, in order to preserve these products, oxygen is often excluded. Oxygen (O2) presence in food packages is mainly due to failures in the packaging process, such as mixture of gases containing oxygen residues, or inefficient vacuum. Vacuum packaging has been widely used to eliminate oxygen in the package prior to sealing. However, the oxygen that permeates from the outside environment into the package through the packaging material cannot be removed by this method.

Oxidation reactions happen when chemicals in the food are exposed to oxygen in the air. In natural conditions, animal and plant tissues contain their own antioxidants but in foods, these natural systems break down and oxidation is bound to follow.

Oxidation of food is a destructive process, causing loss of nutritional value and changes in chemical composition. Oxidation of fats and oils leads to rancidity.

Applications
Sweets Nutritional supplements Cashews and other dry fruits Namkeens Masalas (powders) Ready to eat packets Meat products Dairy products

Humidity Indicating Cards

Humidity Indicating cards (HIC) are used to indicate humidity of a closed environment/packing. Humidity Indicating Cards help monitor desiccant activity and are ideal for use with desiccants in any application where moisture control is critical. These can be applicable to Pharmaceutical Industries, Electronics packaging, Optical instrument packaging, Preservation packaging for sensitive components, Bulk packaging etc. Humidity indicator cards are designed to meet standards set forth by military agencies and electronic/semiconductor companies, such as Mil-Spec and JEDEC respectively. Environmentally preferable: free of halogens and heavy metals. There are various indications available like 30-40%, 5-10%, 5-15%, 20-40%, 10-60% etc, they can also be customized. For example if all of the dots are deep blue on a card which is a 10%- 60% card than you can be assured that the humidity in that container is below 10%.

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