Beruflich Dokumente
Kultur Dokumente
dad alleles instead of knocking one out like in Ab production- results in high diversity-which is important MHC1- intracellular bad protein meets proteasome and is degraded, sent to RER and loaded onto MHC1 then sent to golgi MHC2s are corked until they reach the phagolysosome then bind with Ag-prevents unwanted binding
No Ab can have multiple specificities-dangerous MDGAE!!! D is a signaling molecule Once Ab-Ag complex is made, Fc portion changes configuration so a phag can bind to it---opsonization
Innate CMI NK
Activated Phags (TLRs)
Random stuff
All nave B&T cells will apoptose if its corresponding Ag is never found ONLY 1 SPECIFICITY PER Ab, WAY TOO DANGEROUS TO HAVE MULTIPLE SPECIFICITIES Toll Like Receptors are on most phagocytes and recognize highly conserved regions on pathogens They are Pattern Recognition Receptors that distinguish SNS via Pathogen Associated Molecular Patterns LPS on gram neg bacteria has a high affinity to TLR-4 and is a great stimulator of innate immunity Bad guys cannot mutate structures like LPS to avoid detection because it is extremely important for the vitality of the micro-organism Once stimulated, signal transduction that leads to expression of genes that induce inflammation and increase antigen presentation