Beruflich Dokumente
Kultur Dokumente
Databases
Kyoto Encyclopedia of Genes and Genomes Alliance for Cellular Signaling Signal Transduction Knowledge Environment
p53
Protein 53 Produces 53 proteins kiloDaltons Guardian of the genome Detects DNA damages Halts the cell cycle if damage is detected to give DNA time to repair itself
p53
If (damage equals true and repairable = true) halt cell cycle else if(damage equals true and repairable = false) induce apoptosis (suicide)
ataxia-telangiectasia mutated
p53
p53
activates
p21
deactivates
CDK
No cell cycle!
p53
Cancer Drugs
Alkylating agents - interfere with cell division and affect the cancer cells in all phases of their life cycle. They confuse the DNA by directly reacting with it. Antimetabolites - interfere with the cell's ability for normal metabolism. They either give the cells wrong information or block the formation of "building block" chemical reactions one phase of the cell's life cycle. Vinca alkaloids - (plant alkaloids) are naturally-occurring chemicals that stop cell division in a specific phase. Taxanes - are derived from natural substances in yew trees. They disrupt a network inside cancer cells that is needed for the cells to divide and grow. all inhibit the cell cycle
Systems that are robust against common perturbations are often fragile to new perturbations (vulnerability of complex networks)
Whats to come?
Current work is on small sub-networks within cells.
Feedback circuit of bacteria chemotaxis Circadian Rhythm Parts of signal-transduction pathways Simplified models of the cell cycle Models of the Red blood cells
Whats to come?
Research has begun on larger-scale simulations
Biochemical network level Simulation of Epidermal Growth Factor (EGF) signal-transduction cascade The Physiome Project
Biochemical Networks
Problem: The behavior of cells is governed and coordinated by biochemical signaling networks that translate external cues (hormones, growth factors, stress, etc.) into adequate biological responses such as cell proliferation, specialization or death, and metabolic control. Motivation: Deep understanding of cell malfunction is crucial for drug development and other therapies.
Available: [online] http://www.brc.dcs.gla.ac.uk/projects/bp s/bps_slides/bps_slides.pdf
Biochemical Networks
Biochemical Networks
Concurrency Theory
Concurrent, communicating systems have been the subject of intense study by Computing Scientists. Rich theories and tools have been developed to aid in design, analysis and verification of such systems. Concurrent systems are inherently complex. To manage complexity, theories and tools have been developed to allow programmers to simulate behaviour. Simulators allow the analysis of traces through concurrent executions and provide a testbed for experimentation. At a more abstract level, temporal analysis involves proving that a concurrent system adheres to a temporal property, i. e. it can be shown that a network protocol always delivers data packets in the same order they were sent.
Concurrency
A concurrent system is one where multiple processes exist at the same time. These processes execute in parallel and potentially interact with each other. As an example of a concurrent system, consider an internet banking site. The server and multiple client processes exist at the same time, with interactions occurring between the individual clients and the server.