Sie sind auf Seite 1von 19

M.

PRASAD NAIDU
Msc Medical Biochemistry,
Ph.D Research scholar.

1
outline
Immunity
1.introduction
2.types of immunity
innate immunity
acquired immunity
natural immunity
artificial immunity


5 May 2014 2
IMMUNITY
The term immunity refers to the resistance exhibited by the host
towards infection caused by micro organisms and their
products(toxins).
This is based on the property of self and non self recognition. That
means immunity is carried out by the process of recognition and
disposal of non self or materials that enter the body.
Immune response is the reaction of the body against any foreign
antigen.
But protection against infection disease is only a part of it.
5 May 2014 3
5 May 2014 4
Innate immunity
It is comes because of genetic and constitutional
make up.
It has no relation ship with previous bacterial
infection and immunisation.
It acts as first line of deffence agenest infections,
micro organisms, their products before they cause
disease.


5 May 2014 5
The various non specific diffenc mechanisms are
present.
1.anatomical and physical barriers.
2.physiological and chemical
barriers.
3.biological barriers.
4.general barriers.
5 May 2014 6
Physiological and chemical barriers
The barriers prevent the entry of pathogens to
resist infection.
These include
Ex; skin, mucous membrane, coughing and
sneezing, etc.
5 May 2014 7
skin
5 May 2014 8
Mucous membrane
5 May 2014 9
The respiratory , GIT etc. lined by
mucous membrane
It blocks the micro organisms
because of its sticky nature.
coughing and sneezing
the mechanical actions may help in
driving out the foreign particles that
enter the digestive and respiratory
Physiological and chemical barriers
Human milk: this is very rich in anti bacterial substances.
Ex:IgA, lacto feritin, neuraminic acid etc. they fight against
E.coli and stephylococci.
Secrition of the digestiv tract: stomach as microbicidal effect. This is
due to the presence of Hcl in the gastric juice. This Hcl is secreted by
oxyntic cell lining stomach.
Nasal secretion and saliva:
Inter ferans:
Compliment:

5 May 2014 10
Biological barriers
These includes mono nuclear phagocytic system which was
originally called reticulo endothelial system(RES).
Biological barriers include endocytosis.
Endocytosis: it is the process in which cells absorb materials from
the out side of the environment by engulfing them with their cell
membrane.
Types: the absorbing of material from the out side of the
environment of cell is comanly divided in to 2 types.
1.Phagocytasis.
2.pinocytosis
5 May 2014 11

5 May 2014 12
General barriers
age: the very young and very old are most susceptable to
infections.
Ex: 1. fetus is protected by placental barriers.
2.at old stage people have reduce or loss the host
defences.
Racial immunity:
Individual immunity:
5 May 2014 13
Acquired immunity
The acquiring of immunity from out side source is known as acquired
immunity.
It is result of action of 2 major groups of cells.
1.lymphocytes
2.antigen presenting cells
This immunity is initiated by the recognition of a foreign antigen and the
response to this recognition.
It is highly adaptive and has 4importent features.
1.antigen specificity.
2.diversity.
3.immunological memory.
4.recognition self from non-self.
5 May 2014 14
5 May 2014 15
Active immunity
It is the production of immunity against particular organisms
after exposure.

Natural active immunity:
This immunity develops by natural processes like
infections.
Ex:the infection like small pox are cured by the active
function of the immune system.
Artificial active immunity:
here instead of natural infections. Infection is created
artificially by using various types of vaccines. Ex: polio
vaccine, cholera vaccine etc.
5 May 2014 16
Action of lymphocytes and Apcs
Lymphocytes: they poses antigen binding cell surface
receptors.
Antigen presenting cells: they have class-2 MHC on their
surface and they present anti gens to lymphocytes.
This immune response is of 2 types
1.humoral immune response
2.cell mediated immune response.
5 May 2014 17
Passive immunity
Acquiring of the antibodies passively from an immunized donor
to a non-immunized recipient is noun as passive immunity.
natural passive immunity: it occurs when anti bodies are
transferred from the donar to the recipient in a natural manner.
Ex: Transfer of anti bodies from the mother to the feotus
through the placenta (IgGAntibodies)
artificial passive immunity: the transfer anti bodies and
sensitised lymphocytes from immunized donar to the non-
immunized recipient artificially.
Ex:antibodies produce in the horse serum and
GMOS(genitically modified organisms).

5 May 2014 18
THANK YOU
5 May 2014 19