Beruflich Dokumente
Kultur Dokumente
Professor Meng
Yunlian
Introduction
Endocrine system is a mediated system, mediating the
growth, development, metabolism, reproduction and
behavior of human body and to maintain the stability of
the inner environment through secreting hormones.
Hormones are molecules secreted by endocrine cells
and function as chemical signals. They could be
classified as nitrogenous hormones and steroid
hormones.
Component
Endocrine system consists of endocrine glands,
endocrine structures and endocrine cells.
Endocrine glands include thyroid gland, parathyroid
glands, adrenal glands, hypophysis (pituitary gland)
and pineal body.
What differences between Endocrine glands and exocrine glands
are there?
Endocrine glands differ from exocrine glands in that
they don’t possess ducts, and their secretions(hormones)
are usually released into interstitial tissue, and then
picked up by capillaries.
Endocrine structures
Islet of pancreas and corpus luteum in ovary.
Endocrine cells
There are some endocrine cells distributed in the
epithelium lining the digestive tract and respiratory
tract, in placenta, in heart and in kidney. These
endocrine cells form diffuse neuroendocrine system.
General structure of endocrine glands
Parenchyma organs
Capsule: CT
Parenchyma: Endocrine cells arrange into nests,
cords, clusters or follicles.
Interstitial substance: CT, rich in capillaries.
Neurohypophysis comes
from nerve tissue of floor
of the diencephalon.
Adenohypophysis
the pars distalis
the par tuberalis
the pars intermedia
Neurohypophysis
:
infundibular stalk
the pars nervosa
Adenohypophysis The pars distalis
There are three cell types
in the pars distalis:
acidophils, basophils and
chromophobes. The cells
form nests or cords, and
there are many sinusoids
among the cell nests. All
cells possess
ultrastructures of the
nitrogenous hormone
secreting cells.
Acidophils
LM: round or ovoid, eosinophilic granules
Function of acidophils
There are two subtypes of acidophils according to the
hormones they produce : somatotropic cells and
mammotropic cells.
cells
Function:
i. degranulated cells
ii. under-development cells
The par tuberalis
Most of the cells of pars tuberalis are basophils , and
are arranged in cords alongside the blood vessels
and secrete ganodotropins.
The pars intermedia
Structure
The basophils form
cords and folicles.
Function
Basophils secrete α-
MSH .
Blood supple of
adenohypophysis
Hypophyseal portal system
Superior hypophyseal
arteries→primary capillary
plexus(infundibular stalk)
→hypophyseal portal
veins→secondary capillary
plexus(the pars distalis)
→vein sinusoids(small vein)
Relationship between adenohypophysis and
hypothalamus
Constitutes 80 ~ 90% of
total volume.
Can be subdivided into
three zones:
zona glomerulosa,
zona fasciculata,
zona reticularis
Zona glomerulosa constitutes 5 ~ 10% of cortex volume
LM
small, low columnar
or polygonal cells
arranged into nest or
cluster
deep stained
EM: ultrastructures of steroid-hormone secreting cells
SER
M-with
tubular-
vesicular
cristae
L
Function of zona glomerulosa
Secreting mineralocorticoid
aldosterone
Stimulating reabsorption of sodium and releasing of
kalium.
Zona fasciculata constitutes 78% of cortex volume
LM
large, polygonal or
columnar cells
arranged into cords
light stained
EM
ultrastructures of
steroid-secreting
cells: more lipid
droplets
Function of zona fasciculate
Secreting glucocorticoid
cortisol or corticosterone
promote protein and fat transfer into glucose
impair immune reaction
Zona reticularis: constitutes 7% of cortex volume
LM: small polygonal cells, acidophilic cytoplasm,
arranged into cords which form networks.
EM:
ultrastructures of steroid-secreting cells
less lipid droplet and more lipofuscin pigment
central vein
There are brownish cytoplasm granules in the
medullary cells when they fixed by bichromate-
containing fixative. So medullary cells are also called
chromaffin cells.
Besides medullary
cells there are some
Neurons.
Neuron
EM: The medullary cells possess ultrastructures of the
nitrogenous hormone secreting cells.
The granules of medullary cells contain epinephrine
or norepinephrine.
Function of medullary cells:
Secreting epinephrine and norepinephrine.
neuropeptide Y, enkephalin
Function of epinephrine
i. increase the heart rate
ii. dilate blood vessels
Function of norepinephrine
i. increase blood pressure
ii. increase the flow speed of blood
The blood Supply of
adrenal glands
Thyroid gland
Colloid is
iodinated
thyroglobulin.
Follicular epithelial cells
Structure of follicular epithelial cells
LM: usually simple cuboidal epithelium
inactive flattened
more active columnar
spherical nucleus
EM: ultrastructures of nitrogenous-hormone secreting cells
RER, Golgi complex, secretory granules
microvilli , lysosome, phagosomes.
Function of follicular epithelial cells
i. Synthesis of thyroglobulin
ii. Iodination of thyroglobulin
ⅲ. Storage of iodinated
thyroglobulin as
colloid in follicular cavity.
ⅳ. Engulfing of iodinated
thyroglobulin, forming
phagosomes .
ⅴ. Digestion of iodinated
iodinated thyroglobulin
into T3 and T4
ⅵ. Release of T3 and T4
Function of thyroid hormones
increase the basal metabolism rate
promote the cell growth
raise body temperature
increase heart rate
play a role in foetal and neonatal development of CNS
A diet low in iodine hinders the synthesis of thyroid
hormones, causing hypothyroidism. Thyroid
hypertrophy as a result of increased thyrotropin
secretion causes the disorder known as iodine
deficiency goiter, which occurs endemically in some
regions of the world.
Mechanism of feedback
Myxedema
Adult hypothyroidism
causes myxedema.
Cretinism
Children hypothyroidism
from birth causes
cretinism characterized
by arrested physical and
mental development.
Parafollicular cells
distribute between follicular cells and in interstitial
tissue.
Structure of parafollicular cells
LM: larger ovoid or polygonal, pale-stained
EM:
ultrastructures of nitrogenous hormone secreting cells
Function of parafollicular cells
Secreting calcitonin
Action of calcitonin
Promoting activity of osteoblast and suppressing the
absorption of calcium in gastrointestinal tract and renal
tubule. Calcitonin thus lowers blood calcium
concentration and increases osteogenesis.
Parathyroid Glands
The parathyroid
glands are 4 small
glands. They are
located behind the
thyroid gland, one at
each end of the upper
and lower poles,
usually in the capsule
that covers the lobes
of the thyroid.
Sometimes they are
embedded in the
thyroid gland.
Each parathyroid gland is
contained within a
connective tissue capsule.
These capsules send septa
into the gland.
The endocrine cells of the
parathyroid gland are
arranged in cords. There
are 2 types of cells: the
chief cells and the oxyphil
cells.
The chief cells
LM:
The chief cells are small
polygonal cells with a slight
acidophilic cytoplasm. A
round nucleus locates in the
central of the cell.
EM:
Ultrastructures of nitrogenous
hormone secreting cells
RER, Golgi complex,
secretory granules
Function of chief cells
Secreting parathyroid hormone
Action of parathyroid hormone
Increasing the number and activity of osteoclasts and
thus promotes the absorption of the calcified bone
matrix and release of calcium into the blood. Indirectly
increasing the absorption of calcium from the
gastrointestinal tract by stimulating the synthesis of
vitamin D, which is necessary for this absorption.
The effect of parathyroid hormone is opposite to that of
calcitonin.
What cells can secrete calcitonin?
In addition to increasing the concentration of calcium,
parathyroid hormone reduces the concentration of
phosphate in the blood.
The oxyphil cells
The oxyphil cells
constitute a smaller
population. They are
larger polygonal cells, and
their cytoplasm contains
many acidophilic
mitochondria with
abundant cristae. The
function of the oxyphil
cells is not known.
Pineal Gland
The pineal gland is also known as the epiphysis cerebri,
or pineal body. It is found in the posterior extremity of
the third ventricle.
The pineal gland is covered by piamater. Connective
tissue septa (containing blood vessels and unmyelinated
nerve fibers) originate in the piamater and penetrate the
pineal tissue. Along with the capillaries, they surround
the cellular cords and follicles, forming irregular
lobules.
The pineal gland consists of several types of cells,
principally pinealocytes and astrocytes.
Pinealocytes have long and tortuous branches and have a
slightly basophilic cytoplasm with large irregular or
lobate nuclei. These cells produce melatonin and several
other peptides .
Melatonin can regulate circadian and rhythmic changes
in the secretory activities of the gonads and other organs.
Diffuse neuroendocrine system(DNES)
Components
Scattered single endocrine cells
APUD cells (amine precursor uptake and decarboxylation cells)
can synthesize and secrete amine and peptide