STORAGE OF DOSAGE FORMS

CONTENTS :
DEFINITIONS
CLASSIFICATION
NEED FOR STORAGE OF DOSAGE FORM
STORAGE CONDITIONS FOR DOSAGE FORM
DIFFERENT CONTAINERS FOR STORAGE
CONCLUSION

DOSAGE FORMS
SOLIDS


TABLETS
CAPSULES
POWDERS
LIQUIDS



MONOPHASIC
BIPHASIC
SEMISOLIDS

OINTMENTS
CREAMS
PASTES
SUPPOSITORY
GASES



INHALATIONS
AEROSOLS
DEFI NI TI ONS : -
DOSAGE FORM:
Completed form of the pharmaceutical
preparation in which prescribed doses of
medication are included.
Examples: Tablets, Liniments, Ointments,
Powders ,Lotions etc.
STORAGE:
It simply means keeping things at a place
,till it is used ,so as to preserve the same
properties.
NEED FOR STORAGE OF
DOSAGE FORMS
If the drug is not properly stored and on exposure
to air,heat, light and microbes results in
degradation ,loss of efficacy and even cause
toxicity.
Light can bring about photolytic decomposition due
to exposure to certain wave length of light.
Air present inside the container may catalyse
oxidative degradation or other chemical changes.
Moisture effects the stability of moisture sensitive
preparation.

Sterile products are required to maintain sterility
implying exclusion of microbes.
Certain drugs on exposure to air undergoes auto-
oxidation and emulsified lipids are sensitive to
attack.
So proper storage of drugs is required which
are sensitive to air,light,moisture.
The stability of drug depends on temperature and
pH.
ex:- Ampicillin is stored at low temperatures (2 8
c).
Ampicillin in solution is not stable at pH > 7.
contd
STORAGE CONDITIONS INDIAN STANDARDS AS PER I P-1996 .
COLD TEMPERATURE NOT EXCEEDING 8 C
AND USUALLY BETWEEN 2 - 8 C
COOL ANY TEMPERATURE BETWEEN 8 25 C
WARM ANY TEMPERATURE BETWEEN 3040 C
EXCESSIVE HEAT ANY TEMPERATURE ABOVE 40 C
FREEZER TEMPERATURE BETWEEN -25 TO -10 C
ROOM TEMPERATURE TEMPERATURE PREVALING AT
WORKING AREA
DRY PLACE AVERAGE RELATIVE HUMIDITY NOT
EXCEEDING 40%

If no specific storage directions are given then conditions include protection from
moisture ,freezing and excessive heat.
ON THE LABEL MEANS
DO NOT STORE OVER TO BE STORED IN
8 C REFRIGIRATOR (2 -8 C)
DO NOT STORE OVER TO BE STORED AT
30 C ROOM TEMPERATURE
DO NOT FREEZE KEEP IN
REFRIGERATOR
PROTECT FROM AT NORMAL HUMIDITY&
MOISTURE AT ROOM
TEMPERATURE
PROTECT FROM STORE IN LIGHT
LIGHT RESISTANT
CUP-BOARD
STORAGE CONDITIONS FOR
STORING DIFFERENT DOSAGE
FORMS
Dosage
form
Drug Storage condition Use
Tablets
Paracetamol Store it at room
temperature
Keep away from excess
heat and moisture.
Analgesic,
Anti-pyretic,
Anti- inflammatory
Capsule B-complex Keep in brown
colour/amber colour glass
bottles to protect from
light.store it room
temperature.
vitamin
supplement
syrup codeine Keep it in brown colour
glass bottle to protect from
light. Keep in cool place.
Anti-tussive,
Anti-diarrhoel,
Analgesic.
Lotion Calamine Store in well closed
container
protective
Emulsion Liquid parrafin

Porcelis pestis
emulsion.
Store in glass container
and keep in cool place
Store at 2 8 c . Should
be 15 25 c before use.

laxative.

To decrease
swine fever in
pigs.
Suspension Milk of
msagnesia
Store in a cool in and dark
place and keep in air tight
plastic containers.
Antacid.
Ointment clotrimazole Store in acool and dark
place.keep in plastic
tubes.
Anti-fungal.
Cream Extract of
jivanti,manjisth
a (ayurvedic)
Store in cool and dark
place. Keep in plastic
tubes.
Healing and
soothing of
wounds.
Parenterals Ampicillin Vials should be stored
at 2 8 c for 3 weeks.
For long storage they
should be stored at
-20 c for 4 6 months.
Anti-biotic
Opthalamic Tetrazoline Hcl Store in low
temperature and keep
them in amber colour
glass bottles.
used when
irritation and
redness caused
by cold
Powders clotrimazole Store in cool and dark
place in a plastic
container.
Anti-fungal
Gel aloe Store in cool and dark
place away from direct
sunlight
DIFFERENT CONTAINERS USED FOR
STORAGE
1. WELL CLOSED:-It protects the container from
contamination with extraneous solids under
normal conditions of storage, handling, transport &
prevent unintentional release of the contents.
2. AIR TIGHT :-It gives protection against extraneous
solids, liquids, vapours under normal conditions of
storage, handling, transport. It prevents changes
due to efflorescence, deliquescence, &
evaporation.
3.SECURELY CLOSED:- This is a air tight container
with a means of preventing unintentional
displacement of the closure.

4.HERMETICALLY CLOSED:-It is impervious to air
and other gases under normal conditions of
storage, handling & transport. Ex:- Glass
ampoule sealed by fusion.
Liquid oral preparations
a) Intended to be swallowed (elixirs ,emulsions)
-Glass bottles
b) Not intended to be swallowed ( mouth washes , gargles)
- Ribbed oval glass bottles
Semisolid preparations - creams ,jellies ,ointments
-Collapsible metal or plastic tubes
-Glass or plastic pots.


CONTAINERS FOR DIFFERENT
DOSAGE FORMS
Solid unit dose preparations :-
a) Intended to be swallowed or sucked
(Cachets, soft & hard capsules, pills )
b) Intended for use in body cavities
-Glass ,plastics ,aluminium
-plastic ,metal containers
c) powders

1)For oral administration
Bulk powders -Glass & plastic

2) For external use
Dusting - used in body cavities .
insuffalations -Air tight glass/plastic
container
Gaseous dosage forms
(aerosols , inhalations )
- Metals -Tin coated steel
Aluminium
Stainless steel
-Glass -uncoated g lass
coated glass
GLASS
Advantages:
1)Inert , strong and transparent.
2) Entry of micro organisms can be prevented with a proper
closure.
3)Readily available in different shapes and sizes.
4)Glass has good ageing qualities.
5)Coloured glass can be used to protect light sensitive
products.
Disadvantages:
1) Heavy and fragile.
2) Leaching of alkali.
3) Loss of brilliance.
4)Flaking.

PLASTIC
Advantages:
1) Flexible in nature.
2) Less brittle than glass/ non breakable .
3)Light weight.
4)Easily moulded in to number of shapes and sizes.
5)Suitable for container & closure.
Disadvantages:
1)Only few withstand heat with out softening.
2)permeability to water vapour & atmospheric gases is less.
3)May sorb substances.
4)Leach out stabilizers & plasticizers in to solutions.
5) May interact with certain chemicals & become soft.
6)Relatively expensive.
7)Light transmission .




METALS :
ADVANTAGES:
1.Impermeable to light, moisture and gases
2.Rigid and unbreakable.
3.Lables can be directly printed on their
surface.
DISADVANTAGES:
1.Shed metal particles into product.
2.Expensive.
3.Chemically reactive in nature.
Working of Stores Department