Adrenogenital syndrome

Etiology
- Caused by partial or complete
failure, one or more enzymes
required for the synthesis of steroids.
- Genetically inherited in an
autosomal recessive
Pathophysiology
- C-20 Deficiency hidrosilase
Is the most severe type and is equivalent
kelaianan early steroid synthesis
Baby boy failed to produce intrauterine
testosterone. Eventually overrun by the
adrenal glands, causing cholesterol hipeplasia
adrenal lipids.
In the event of severe biochemical
disturbances will cause death

Deficiency C-3 Beta dehydrogenase
Affect the gonads so cortisol is reduced
so that the increased secretion of
corticosteroids. Terajadi consequently
lead to salt retention and hypertension.
had no menstruation In the female
external genitalia tap
pesudohermaprodite In men

C-21 hydroxylase deficiency
Most commonly occurs due to
deficiency of which causes excess
cortisol andorgen.
heavy state spending on Natriium after
birth and fatal
normal external genitalia > Baby boy
rapid growth Baby female genitalia

C-11 Deficiency A hidrosilase
The disorder occurs in the last step synthesis
of cortisone and aldosterone. Cortisol in the
blood to normal shingga increased androgen
deosikortikosteron. yng cause virilization and
hipertension
Insufisiency adrenocortical
Acute adrenocortical insufficiency
Etiology and pathology
- Absolute or relative deficiency of cortisol that
occurs suddenly is usually caused by illness or
severe stress.
- Because the bacterial toxin in severe infections
bilateral adrenal hemorrhage due to multiple in
all parts of the bodyOn meningococcal
septicemia mainly by bleeding

Caused by stress, mild infections, in
patients where decreased adrenal
response, for whatever reason or
disruption due to damage to the
pituitary release of ACTH or
corticosteroid and ACTH therapy is
used common cause widely
Chronic adrenocortical insufficiency

EPIDEMIOLOGY
Found in the middle of the last usie land
perlhana berthun for months even years
with no specific complaints.


ETIOLOGY AND PATHOLOGY

Caused by kegaga; corticosteroids am
working. more importantly asalah gluko
and mineralocorticoid deficiency with
symptoms is unclear.
Aldosterone failure tends to cause loss of
sodium and potassium retention and a
decrease in blood glucose.

Pigmentation occurs due to excretion
melonocyte stimulating hormone (MSH)
excessive ACTH secretion is accompanied
by an increase in plasma levels of low
krotisol
Another cause is tuberculosis but more
often idiotpatik
Very rarely caused by secondary
neoplasms and granulomas