Beruflich Dokumente
Kultur Dokumente
in Adenomyosis
Achmad Kemal Harzif
Department of Obstetrics and Gynecology
Faculty of Medicine Universitas Indonesia
Jakarta Indonesia
Outline
Introduction
Health problems related to adenomyosis
Surgical Management in Adenomyosis
Whats the current evidence
Take Home Messages
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
A surgeon is someone who does everything and
knows nothing
Anonymous
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Adenomyosis is defined by the presence of islands of
ectopic endometrial tissue within myometrium
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
EPIDEMIOLOGY
Prevalence reported to range from 5-70%
Adenomyosis at hysterectomy is approximately
20-30%
Five to 25% of adenomyosis are observed in
patient younger than 39 yo
Garcia L, Isaacson K
Journal of Minimally Invasive Gynecology, Vol 18, No 4, July/August 2011
It can be
focal
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Or dIffuse
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Symptoms of Adenomyosis
Symptoms N (%)
Dysmenorrhea 34 (69,39%)
Pelvic pain 7 (14,29%)
Dysmenorrhea and dyspareunia 4 (8,16%)
Dysmenorrhea and pelvic pain 3 (6,12%)
Abnormal uterine bleeding 1 (2,04%)
Legiantuko A, Wiweko B. Presented at Annual POGI meeting 2013
Not only gynecological symptoms
Taran FA, et al. Fertil Steril, 2010;94:12238
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Reproductive BioMedicine Online (2012) 24, 3546
Factors that may contribute
1. Altered uterine peristaltic activity
2. Altered endometrial function and receptivity
3. Impaired implantation
4. Altered decidualization
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Placenta 34 (2013) 100-105
Adenomyosis
Endometriosis
Miscarriage Preterm birth
PPROM IUGR Preeclampsia
Progesterone
resistance
Defective deep
decidualization
Vascular resistance in JZ
Defective trophoblastic
invasion
Thickened
JZ
Endothelial
Dysfunction ?
Treatment Options
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
1. Definitive treatment : Hysterectomy
2. Medical treatment
Combined oral contraceptive
Progestins
LNG-IUS
GnRH agonist
3. Conservative surgery
Garcia L, Isaacson K
Journal of Minimally Invasive Gynecology, Vol 18, No 4, July/August 2011
Classification of Uterine-Sparing Techniques
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
1. Complete excision
2. Partial excision
3. Non excisional technique (high frequency
ultrasound, radiofrequency, artery
occlusion
Curr Opin Obstet Gynecol 2012, 24:259 264
Adenomyosis Resection
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Refers to the surgical excision of myometrial
tissue affected with adenomyosis in patients
wishing to retain their uterus
Curr Opin Obstet Gynecol 2012, 24:259 264
Difficulties in conservative management
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Grimbizis G, et al. Fertil Steril 2013, Article in Press
1. Complete excision of lesion remains
inaccurate
2. Excision of adenomyotic tissue is always
accompanied by excision of myometrium
3. High recurrence rate
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Nishida M, et al. Fertil Steril 2010;94:7159
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Nishida M, et al. Fertil Steril 2010;94:7159
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Reproductive BioMedicine Online (2011) 22, 9499
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
RESULTS OF CONSERVATIVE SURGERY IN ADENOMYOSIS
NISHIDAS TECHNIQUE
n = 44
Mean operative time 159 + 43,7 minutes
Mean blood loss 745 + 56 ml
Preoperative VAS 9,4 + 1,0
Postoperative VAS 0,8 + 1,0
Pregnancy 2 patients
Recurrence after
surgery
3 patients
Nishida M, et al. Fertil Steril 2010;94:7159
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
RESULTS OF CONSERVATIVE SURGERY IN ADENOMYOSIS
OSADAS TECHNIQUE
Reproductive BioMedicine Online (2011) 22, 9499
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
RESULTS OF CONSERVATIVE SURGERY IN ADENOMYOSIS
OSADAS TECHNIQUE
Reproductive BioMedicine Online (2011) 22, 9499
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
RESULTS OF CONSERVATIVE SURGERY IN ADENOMYOSIS
Legiantuko A, Wiweko B. Presented at Annual POGI meeting 2013
49%
32%
19%
Operative Management
Hysterectomy
Conservative
resection
Osada's
techique
Operative method Mean Age
Hysterectomy 45,52 + 3,612
Conservative resection 35,83 + 3,505
Osadas technique 33,63 + 3,483
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Legiantuko A, Wiweko B. Presented at Annual POGI meeting 2013
One year follow up
82%
18%
0%
Pain
No Symptoms
Reduced Pain
Persistent
symptoms
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Mrs I, 35 years old
Osada adenomyosis resection in 2010
By c-section born 2770 gram baby boy AS 9/10
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Legiantuko A, Wiweko B. Presented at Annual POGI meeting 2013
Fertility outome
Natural
conception
8 patients
IVF
2 patients
Elective CS
2 patients
Elective CS
2 patients
Ongoing
pregnancies
2 patients
Miscarriage
2 patients
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Human Reproduction Update, Vol.18, No.4 pp. 374392, 2012
No randomized controlled trials were found
We have refrained from doing any meta-analysis due to
the study designs
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Fertil Steril 2013, Article in Press
Systematic literature review
64 studies dealing with 1,049 patients were
identified
Conservative uterine-sparing surgery for
adenomyosis classified as
(1) complete excision of adenomyosis,
(2) incomplete removal of the lesion
(3) nonexcisional techniques
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
FERTILTIY OUTCOME
Wish to concieve
182 patients
Total conception
107 patients
(58,79 %)
Full term
deliveries
79 patients
(73,83 %)
Preterm
7 patients
(6,54 %)
Ongoing
2 patients
(1,87 %)
90 patients natural
17 patients IVF
Miscarriage 19 patients (17,76 %)
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Laparotomy or Laparoscopy
Laparotomy has been used for the surgical treatment of
adenomyosis because of the extension of the disease
within the myometrium and the difficulty in suturing the
remaining uterine wedges after the excision.
Adenomyotic foci or for excision of adenomyomas
Laparoscopy ?
Grimbizis G, et al. Fertil Steril 2013, Article in Press
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
Fertil Steril 2013, Article in Press
Which technique is better ?
There is no strong evidence to indicate a
technique that secures the best clinical and
reproductive performance
Important aim of surgery
maximize the amount of adenomyosis excised
empower the uterine wall integrity so that a
future pregnancy can be sustained
TAKE HOME MESSAGES
Introduction
Health
problems
related to
adenomyosis
Surgical
Management in
Adenomyosis
Whats the
current
evidence
Take Home
Messages
1. Conservative surgery is an option for
adenomyosis in which preservation of uterus is
still needed
2. No technique proven to be superior in
adenomyosis resection
3. The aim of surgery is maximize excision while
maintaining uterine wall integrity
Indonesian Reproductive Medicine
Research and Training Center (INA REPROMED)
Ali Baziad, Andon Hestiantoro, Muharam Natadisastra, Kanadi Sumapraja,
Gita Pratama, Herbert Situmorang Eliza Mansyur, Tita Yuningsih, Dyah Pitha, Siti Mariam, Endang Kurdiningsih,
M Priangga, Valencia Yuwono, Nadia Safira
Acknowledgement