Dr. H. Toton Suryotono, Sp.PD Malnutrisi Malnutrition can arise from primary or secondary causes, with the former resulting from inadequate or poor-quality food intake and the latter from diseases that alter food intake or nutrient requirements, metabolism, or absorption, particularly diseases that cause acute or chronic inflammation.
Traditionally, the two major types of PEM have been marasmus and kwashiorkor. Marasmus has been considered the end result of a long-term deficit of dietary energy, whereas kwashiorkor has been understood to result from a protein-poor diet.
Harrisons principles of internal medicine. 18 th edition. BMI Classification BMI = kg/m2 = 32/(1.5) = 14.22 Classification BMI (kg/m) Underweight <18.50 Severe thinnes <16.00 Moderate thinnes 16.00-16.99 Mild thinnes 17.00-18.49 Normal Range 18.50-24.99 Overweight 25.00 Pre-obese 25.00-29.99 Obese 30.00 Obese class I 30.00-344.99 Obese class II 35.00-39.99 Obese class III 40.00 Source : adapted from WHO 2006 The High-Risk Patient Underweight (body mass index <18.5) and/or recent loss of 10% of usual body mass Poor intake: anorexia, food avoidance (e.g., psychiatric condition), or NPO status for more than about 5 days Protracted nutrient losses: malabsorption, enteric fistulas, draining abscesses or wounds, renal dialysis Hypermetabolic states: sepsis, protracted fever, extensive trauma or burns Alcohol abuse or use of drugs with antinutrient or catabolic properties: steroids, antimetabolites (e.g., methotrexate), immunosuppressants, antitumor agents Impoverishment, isolation, advanced age Harrisons principles of internal medicine. 18 th edition. Physiologic Characteristics of Hypometabolic and Hypermetabolic States Physiologic Characteristics Hypometabolic, Nonstressed Patient (Marasmic) Hypermetabolic, Stressed Patient (Kwashiorkor Risk * ) Cytokines, catecholamines, glucagon, cortisol, insulin
Metabolic rate, O 2
consumption
Proteolysis, gluconeogenesis
Ureagenesis, urea excretion
Fat catabolism, fatty acid utilization Relative Absolute Adaptation to starvation Normal Abnormal Estimating Energy and Protein Requirements A patient's basal energy expenditures (BEE, measured in kilocalories per day) can be estimated from height, weight, age, and gender by using the Harris-Benedict equations : Women: BEE = 655.10 + 9.56W + 1.85H 4.68A (W is weight in kilograms; H is height in centimeters, and A is age in years)
655.10 + 9.56(32) + 1.85(150) + 4.68(15) = 1,309 kkal/day Ketidakseimbangan energi merupakan faktor utama kegagalan pertumbuhan dan malnutrisi pada anak dengan kelainan jantung bawaan yang memiliki tingkat metabolisme yang lebih tinggi. Sejumlah faktor dapat menjadi penyebab terjadinya malnutrisi pada anak dengan PJB, antara lain hipoksemia, asupan kalori yang tidak adekuat, hipermetabolisme, malabsorpsi, dan faktor hormon pertumbuhan.