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MANAGEMENT OF CHIDHOOD
URYNARY TRACT INFECTION
A. Definition of Terms
Urinary tract infection (UTI)
Recurrent UTI
B. Diagnosis of UTI
0c
I. Guidelines for diagnosis:
1. All infants and children with unexplained fever 38.5
Age group
Fever
vomiting
Lethargy
Irritability
Poor feeding
Failure to thrive
Abdominal pain
Jaundice
Hematuria
Offensive urine
Preverbal
Fever
Abdominal pain
Loin tenderness
Vomiting
Poor feeding
Lethargy
Irritability
Hematuria
Offensive urine
Failure to thrive
Verbal
Frequency
Dysuria
Dysfunctional
voiding Changes
in continence
Abdominal pain
Loin tenderness
Fever
Malaise Vomiting
Hematuria
Offensive urine
cloudy urine
Infants and
children 3
months
Upper tract
Lower tract
Age
<3 years
3 years
Fever
Voiding dysfunction
Suprapubic pain
Loin pain
Raise
Normal
Creative protein
Renal involvement :
a) Raised creatinine
b) Area of edema on power
Doppler ultrasound
c) Photopenic area on DMSA scan
III. Work-up
1. Dipstik
Leucocyte (+)
Leucocyte (-)
Nitrite (+)
Nitrite (-)
Not UTI
Explore other causes of
fever
Send for microscopy if
with known structural
abnormalities
Probability of infection
(%)*
Suprapubic
Aspiration
>99%
Transurethral
Catheterization
>105
95%
Infection likely
Suspicious, repeat
Infection unilikely
Clean void
Boy
Girl
104
3 specimens 105
2 specimen 105
1 specimens 105
5 x 104 to 105
104 to 5 x 104
<104
5 x 104
103 -<5x 104
103
Infection likely
95%
90%
80%
Suspicious, repeat
Symptomatic:
Suspicious, repeat
Asymptomatic:
infection
Unlikely
Infection unlikely
C. Imaging
I. Goals of imaging :
1. To identify those with underlying structural renal abnormalities, especially
obstructive uropathies requiring surgery
2. To identify those with factors predisposing them to increased risk of recurrent
UTI
3. To identify those with renal parenchymal damage (primarity in those with
severe or bilateral disease), predisposing them to increased risk of:
a. Hypertension (38%)
b. Pre-eclampsia in pregnancy
10
13
14
15
0,4 to <1 cm
None
DMSA
Observe
DMSA
VCUG
Atypical UTI
Recurrent UTI
Ultrasound :
Small kidney
Dilated ureter
Thickened
bladder wall
16
2. Girls
Ultrasound of urinary
tract
PC dilatation
<1cm
21cm
Age <6 yrs
Age 6 yeas
DMSA
Observe
(+) SCAR
No scar
recurrent UTI
DMSA + VCUG
17
D. Treatment
I. Principles of treatment
1. The drug of choice should be based on the resistance
patterns of the uropatogens in the hospital as well as of
recent antibacterial treatment received by the patient.
2. The drug should have minimal adverse effects on the
major organ systems.
3. A high concentration of the drug should be preesnt in the
urine after administration.
4. Oral antibiotics are efficacious in both lower and upper
tract infections.
5. Second and third generation cephalosporins should be
avoided as empiric therapy in non-atypical UTI to avoid
increase in antibiotic resistance.
6. Urinaru antiseptics such as nalidixic acid and
nitrofurantoin should not be the initial drug choice in
upper tract UTI
18
Antibiotic
Frequency
Therapeutic dose
(mg/kg/dose)
Prophylactic dose
(mg/kg ON)
Ampicilin/sulbactam
(Unasyn)
Q12H
15-25 (ampicilin)
(maximum 2 g)
Amoxcilin
Q8H
Amoxycilin/Clauvulani
c acid (Augmentin 7:1)
Q12H
10-25 (amoxcilin)
(maximum 1g)
Cefaclor
Q8H
10-15 (maximum
500mg)
10
Cephalexin
Q6H
Q12H
7.5
Cefuroxime
Q12-24H
Co-trimoxazole*
Trimethoprim
(TMP1 mg)
Sulphamethoxazole
(SMX 5 mg)
OR Trimethoprim
Q12H
3-4 (TMP)
Q12H
3-4
Nalidixic acid*#
Q6H
15 Q12H
10
19
21
Antibiotic
Route
Frequency
Dose (mg/kg
dose)
Comment
Amikacin
IV,IM
Term Neonate: 15
1 week to 10
years: 25 (D1),
then 18>10
years:20 (D1),
then 15
(maximum 1.5
g/day)
Monitor levels
Through level <5
mg/L
Renal adjusment
Ampicilin
IV,IM
Q12H (W1)
Q6 H (W2-4)
Q4-6H (W4+)
10-25
Severe : 50
(maximum 2 g)
Renal Adjusment
Augmentin
IV, IM
Q8H
30 (maximum 1.2
g/dose)
10-25 (amoxcilin)
Severe :50
(amoxcilin)
Renal adjusment
Cefazolin
IV.IM
Q6H
Q4-6H
10-15(adult 0,5 g)
Severe :50
(maximum 2 g)
Renal adjusment
Cefriaxone
IV, IM
Q12-24H
Q24H(W1)
Q12H(W2+)
25 (Adult 1 g)
Severe : 50
(maximum 2g)
Cefuroxime
IV
Q8H
Q12H (W1)
Q8H (W2)
Q6H (>W2)
25 (Adult 1 g)
50 (maximum 2 g)
Gentamicin
IV,IM
Q8H
Q12H(W1)
Q8H (W2)
Q6H(>W2)
Renal adjusment
Gentamicin
IV,IM
Q24H
Term neonate to
Monitor levels