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ACCUMULATIONS
PATHOLOGIC
CALCIFICATION
Presented by: Dr. Wajiha Alamgir
M.Phil Oral Pathology
Armed Forces Institutue of Pathology,
Raawalpindi, Pakistan
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Dr.Wajiha Alamgir
Definition
TYPES
Dystrophic
Calcification
Metastatic
Calcification
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Dr.Wajiha Alamgir
DYSTROPHIC CALCIFICATION
EXAMPLES:
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Dr.Wajiha Alamgir
MORPHOLOGY
Carotid plaque
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Dr.Wajiha Alamgir
HISTOLOGY
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Dr.Wajiha
Alamgir
Dystrophic calcification-Breast
METASTATIC CALCIFICATION
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Alamgir
CAUSES:
1.
Alamgir
2.
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Dr.Wajiha
Alamgir
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Dr.Wajiha
Alamgir
MORPHOLOGY
Same as in dystrophic calcification.
SITES
Principally affects interstitial tissues of
Vasculature
Kidneys (e.g. nephrocalcinosis)
Lungs ( respiratory deficits)
Gastric mucosa
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Alamgir
KIDNEY
LUNGS
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PATHOGENESIS
DYSTROPHIC CALCIFICATION
Two types:
a) Intracellular
b) Extracellular
Pathogenesis involves two steps:
i) Initiation or nucleation
ii) Propagation
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Dr.Wajiha Alamgir
a) Initiation
Extracellular
Calcium
Phosphate
(Action of
(affinity for membrane
membrane-bound
phospholipids)
phosphatases)
Accumulation
Membrane-bound vesicles
Intracellular
Calcium
Accumulation
Mitochondria of dead or
dying cells that have lost
their ability to regulate
intracellular calcium
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Dr.Wajiha Alamgir
b) Propagation
It occurs both intracellularly and extracellularly.
THANK YOU
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