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Antineoplastic Drugs
Cancer is a disease in which cell multiply without
control, destroy healthy tissue and could lead to
death.
Anticancer drugs, also called chemotherapeutic
drugs, or antineoplastic therapy.
The treatment of cancer is generally successful
when the cancerous cells are localized and have
not been disseminated throughout the body. The
optimal treatment is surgical removal of the
affected tissue or exposure by area by means of
radiation or cobalt
CAUTION US
1. Environmental Factors
Chemical Carcinogen
Physical Carcinogen
Viral Carcinogen
2. Dietary factors
3. Genetic predisposition
4. Immune function
Prevention
Early detection
1. Mammography
2. PAP test
3. Stools for occult
4. Sigmoidoscopy/Colonoscopy
5. Breast Self Exam
6. Testicular Self Exam
7. Skin inspection
Diagnostic Test
Biopsy
Bone marrow Examination
Chest Radiograph
Complete Blood Count
CT scan
Liver function studies
MRI
2.
GI Disturbances
Anorexia because of bitter taste in
the mouth from drugs
1.
2.
3.
4.
5.
6.
7.
8.
Alkylating Agents
Kills cell by forming cross links on the
DNA strands causing abnormal chemical
bonding between the adjacent DNA
molecules. This belongs to CCNS
category. Effective against may type of
cancer.
Acute and chronic leukemia
Lymphoma
Multiple myeloma
Solid tumors (breast, ovaries, uterus,
lungs)
Cyclophosphamide
(Cytoxan)
Axn: Inhibition of
protein synthesis through
Carboplatin (Paraplatin)
Route: IV infusion up to 360 mg/ m2, every 4
weeks interval
Side effect: bone marrow depression
Nausea and vomiting
Electrolyte loss
Hemolytic anemia
Nursing Implication:
1. Monitor for signs of hematological disorder.
2. Discard solution 8 hours after dilution.
3. Anaphylactic like reaction may occur within
minutes of administration. Have epinephrine,
corticosteroids and antihistamine available at
bedside.
Antimetabolites
Have the ability to interfere with
various metabolic actions of the cells
results in the cell destruction or
inability to replicate. The
antimetabolites are single cell cycle
specific agents that appear on
dividing cells during the S phase of
the cell cycle.
Fluorouracil, 5 FU (Adrucil)
Inhibition of DNA and RNA synthesis
Route: I.V.
Dosage: 6 to 12 mg/kg/day (250mg/5ml
amp)
Side Effect: Bone marrow depression
Nausea, oral and G.I. ulceration
diarrhea, and alopecia
Nursing Implication
1. Monitor client for signs of hematologic
changes.
2. Do not refrigerate
3. Protect solution from light
Methotrexate
(Amethopterin)
Folic Acid Antagonist
Doxurubucin (adriamycin)
Bleomycin Sulfate
(Blenoxane)
Nursing Implication
1. Monitor client for development of
pulmonary toxicity.
2. Powder should be stored in ref.
3. Reconstituted solution is stable for 24
hours at room temperature.
Other anti-tumor antibiotic
Dactinomycin (cosmegen)
Plicamycin (mithracin)
Valrubicin (valstar)
Nursing Implication
1. Do not administer by IV push
2. Capsules should be kept refrigerated.
3. Monitor vital signs.
4. Monitor liver function
VINBLASTINE (Velsar)
Route: IV
VINCRISTINE (oncovin)
Route: IV
DEXAMETHASONE
Route: IV
Dosage: initially 0.5mg-1.5mg/kg/day
in every 6 hours
Primary indication: Nausea and
vomiting with chemotherapy