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Basic Biology
Hyaluronan is a polysaccharide
Repeating disaccharide which contains Glucuronic
Hyaluronan
NATURE OF PRODUCT
BY ANISAH BINT ISMAIL, ALGHALIAH ALRUJAIB, SARA
GREEN
Products
Beauty
products
Knee
osteoarthritis
injection
Skin
wounds
healing
Products of
Hyaluronan
Applications
1.
ADVANTAGE : The side effects are mild such as temporary pain and swelling
after injection.
DISADVANTAGE : Some people might have a slight allergic reaction and the
injections have to be taken frequently as the pain relief is only temporary.
Applications
2. Beauty product
Hyaluronan is able to absorb up to 1000 times of its weight in H2O, therefore it
Applications
Injury results in hyaluronan fragmentation in hyaluronan of very low molecular
weight. These small fragments activate the immune cells and thus support the first
process of healing which is inflammation.
Hyaluronan is able to eliminate scar formation during the wound healing process.
http://www.hyiodine.com/patients-hyaluronan-in-wound-healing
Hyaluronan
PROCESS OF PRODUCT
BY ASIF HASSAN, ANAND SUBASH,WAJAHAT NASEEM,
JUNIOR AGBOOLA
Hyaluronan
SAFETY ISSUES
BY ATHANASIE MUNYANEZA, HARRY WILKINSON,
CALLUM DYKES, ALEXANDER CHILVERS
means it aids the spread from one part of the body to other
parts. It does this by protecting the cell from physical
damage.
Another use is in injections aimed to help people suffering
Hyaluronan
ENVIRONMENTAL ISSUES
BY GIORGIO DE MITRI, SILVIA LUNGU,
NADHIRAH MUHAMMAD FITHRI
Osteoarthritis
Ageing skin
Cataracts
https://www.hsc.com.my/ort_arthroscopic.php
http://www.wisegeek.org/what-ishyaluronic-acid.htm
Anti-ageing treatment:
In general, the side effects are
Hyaluronic acid has not been tested in pregnant women or women who are
breastfeeding. It is important to tell your doctor if you are, or intend to
become pregnant or if you are breastfeeding.
Hyaluronan
COMMERCIAL AND ECONOMIC
ISSUES
BY MONIKA ROWCZENIO, DINESH SELVANATHAN,
JIULIO LAFONTANT
Scope
Hyluronan has a world market value of US$500M and
is sold for up to US$100K per kg (Heinz T.J. 2013).
Production is based on two methods:
o Extraction from animal tissues
o Microbial Fermentation using bacteria strains
Pharmaceutical Value
Hyaluronan has a pharmaceutical value of $US170m (Novozymes 2012).
Below are the figures for the Hyaluronan Division of Lifecore, one
company which is extensively involved in its usage .
6,000,000.00
5,000,000.00
4,000,000.00
2007
2006
3,000,000.00
2,000,000.00
1,000,000.00
0.00
Net sales
Gross Profit
Disadvantages
Well-established technology
Natural product
As you can see, there are currently more issues than benefits in extracting
hyaluronan from animal tissues.
Hyaluronan
COMPETING TECHNOLOGY
BY TAYLOR OSBORNE, JOSHUA STEEL, BEN FOWLER,
CHIBUIKEM NWAYO
Competition
Treatment of osteoarthritis of the knee
Competition
Post-operation induced tissue healing, notably after
cataract surgery
Laser treatment
Stem cells
[Berthiaume, 2009]
Phototherapy
Barrier repair moisturiser
Coal tar
Vitamin B6
[EczemaNet, 2007]
Hyaluronan
FUTURE OF PRODUCT
Future perspectives
Intra-articular hyaluronic acid viscosupplementation is becoming popular as nonoperative treatment for patients with
osteoarthritis.
It enhances the lubricating ability of synovial fluid
after injury. Helping to prevent osteoarthritis.
It contributes to the viscosity of synovial fluid and
so can act as a cushion.
http://huntsvillesportsdoc.squarespace.com/storage/Visco
supplementation2.jpg?__SQUARESPACE_CACHEVERSION=13408091
23371
http://www.trixsyn.com/images/1254_canin
e_02.jpg
Future perspectives
Extensive experimental evidence in cell and animal tumor models have shown that
Hyalurana acts a drug carrier.
Hyluranan attaches to the drug which allows the drug to directly attach onto the
tumours cells. This is because Hyluranan can selectively attach onto tumours cells
via a marker called CD44. This allows the drugs to be more effective as it will not
effect the surrounding healthy cells.
It is an increasingly investigated area for applications to anticancer
chemotherapeutics.
http://www.mdpi.com/ijms/ijms-12-01009/article_deploy/html/images/ij
ms-12-01009f3-1024.png
References
Australian Rheumatology Association . (2011). PATIENT INFORMATION ON HYALURONIC
References
Chiara Schiraldi, Annalisa La Gatta and Mario De Rosa (2010). Biotechnological Production
and Application of Hyaluronan, Biopolymers, Magdy Elnashar (Ed.), ISBN: 978-953-307-1091, InTech, Available from: http://www.intechopen.com/books/biopolymers/biotechnologicalproduction-characterization-and-application- of-hyaluronan
Carmen G. Boeriu, Jan Springer, Floor K. Kooy, Lambertus A. M. van den Broek, Gerrit Eggink.
(2013). International Journal of Carbohydrate Chemistry Volume 2013. Available:
http://www.hindawi.com/journals/ijcc/2013/624967/. Last accessed 20th Nov 2014.
Gary. H. G., Hales C.A., (2004) Chemistry and biology of hyaluronan. [online] Google scholar.
Page 1 available from: books.google.co.uk [accessed 14 October 2014]
Heinz. T.J., (2013) International Journal of Carbohydrate Chemistry. Production Methods for
Hyaluronan [online] Volume 2013 pages 3-6. Available from
www.hindawl.com/journals/iju/2013/624967/ [accessed 19 October 2014
Wikipedia (2014) Glycosaminoglycan [online] Available from:
http://en.wikipedia.org/wiki/glycosaminoglycan [accessed 19 October 2014]
Wikipedia (2014) Hyaluronan [online] available from:
http://en.wikipedia.org/wiki/hyaluronan [accessed 19 October 2014]
(Wikipedia used for background knowledge)
References
Spyros S. Skandalis*, Chrisostomi Gialeli*, , Achilleas D. Theocharis*, Nikos K.