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(HUS)
Characterized by:
MAHA
Thrombocytopenia
Acute Renal Failure
Two general
types:
- D+ HUS
Atypical HUS
Acute gastroenteritis(bloody
diarrhea)
90% cases of HUS
Occurs mostly in young children
Infection with
enterohemorrhagic serotypes of
E. coli (0157:117)
No diarrhea
10% case of HUS
Commonly found in adults
Half are FAMILIAL and Half are
SPORADIC
-Mutation in
-occurs
genes
secondary to
some: drug
cancer
organ
transplantation
Schistocytes
Normocytic anemia
Increased reticulocyte count
polychromatophilia
Mild to moderate decreased in
platelets
Characterized by:
Widespread activation of hemostatic sytem
Resulting in FIBRIN THROMBI formation
throughout the microvasculature
Fragments
Schistocytes
Paucity of platelets
Normocytic anemia
Increased reticulocyte count
polychromatophilia
Clostridia
Clostridial Sepsis
Sepsis with Massive Intravascular hemolysis
Cause by Clostridia Perfringens
Often fatal and is rare complication of infection
It hydrolyses the RBC membrane phospholipid by producing
alpha toxin with phospholipase C spingomyelinase activity
RBC becomes spherical and extremely susceptible to osmotic
lysis
Hematocrit may be 10%
Hemolysis
Due to Venoms, Chemicals,
and Drugs
Venoms
Can induce hemolysis through direct disruption of the RBCs
membrane , alteration of the RBC membrane and initiation of DIC
Caused by envenomation from contact with snakes, spiders, bees,
and wasps
Hemolysis occur acutely or be delayed one or more days after a
bite or stung
In severe cases it causes renal failure and death
Drugs and
chemicals
-oxidative denaturation of
hemoglobin
-leading to formation of
methemoglobin and
Heinz bodies
Laboratory findings:
-Decreased hemoglobin
-Decreased reticulocyte
-Increased serum indirect
bilirubin
-Decreased in serum
haptoglobin
-Heinz Bodies