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DR.SADIA HAROON
Lecture 3 Outline
• Homeostasis
- makes up
~60% of total
body weight
(TBW)
- distributed in
three fluid
compartments.
16% TBW
4% TBW 40% TBW
Fluid is continually
exchanged between
the three
compartments.
16% TBW
4% TBW 40% TBW
Exchange between
Blood & Tissue Fluid
- determined by
four factors:
capillary blood
pressure
plasma colloid
osmotic
pressure
interstitium
Hydrostatic
Pressure
Interstitium
colloid osmotic
pressure
16% TBW
4% TBW 40% TBW
Exchange between
Blood & Tissue Fluid
- not affected by
electrolyte
concentrations
- Edema = water
accumulation in
tissue fluid
16% TBW
Water Gain
2) drink – voluntarily
controlled
Base
A base is any chemical that accepts H+.
Acids and Bases
Most biological buffers consist of a pair of
molecules, one an acid and one a base.
Acids and Bases
Hydrogen ion (H+1 ) is the basis of the pH scale.
pH = - log [H+ ]
0.01 µ M [ H+ ] = pH 8 ↓ [ H+ ] = ↑ pH
0.1 µ M [ H+ ] = pH 7 ↑ [ H+ ] = ↓ pH
Normal functions of proteins (especially
enzymes) heavily depend on an optimal pH.
pH7.35-pH7.45
Acids and Bases
Acid: a chemical that releases H+1 ions.
1) Chemical Buffers
2) Respiratory Control of pH
3) Renal Control of pH
Properties of Water
1. Water has a high specific heat.
- A large amount of energy is required to
change the temperature of water.
2 12 0.01 10-12
4 10 0.0001 10-10
6 8 10-6 10-8
8 6 10-8 10-6
10 4 10-10 0.0001
12 2 10-12 0.01
14 0 10-14 1.0
pH measurement
• pH paper:
1.Broad range (1-14whole no)
2.Narrow range (0.3-0.5pH unit)
• Litmus paper:
-Its neutral point is pH 7.
-Blue colour on alkaline side and red colour on acid side.
pH measurement
• pH meter:
-Electrometric method with
1.Strong acids:
-That ionizes completely.
-High concentration of H ions.
-Free H+ show less tendency to
combine with base. (weakest conjugate)
2.Weak acids:
-Slowly dissociates.
-Give less no of H+ ions.
-Has the strongest conjugate base.
Classification of acids
• Second is based on
volatile/non-volatile:
1.Volatile acid:
-Carbonic acid:20000 m eq/day
2.Non-volatile acid:
-Lactic acid
-Sulphuric acid
-phosphoric acid
Classification of acids
• Second is based on
volatile/non-volatile:
1.Volatile acid:
-Carbonic acid:20000 m eq/day
2.Non-volatile acid:
-Lactic acid
-Sulphuric acid
-phosphoric acid
From Devlin, 3rd ed., Ch 1
Dissociation Constant and pH
• Since normal [HCO3 ] equals 24 mM, there was a decrease of 14.6 mmol of [HCO3
- -
per liter of blood in this patient. This would be approaching the point where, if left
untreated, the HCO3- buffering capacity would be no longer effective in this patient.