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INTRODUCTION
5-2
INTRODUCTION
Extranuclear inheritance
Mitochondria
Chloroplasts
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Right-handed (dextral)
Left-handed (sinistral)
The dextral orientation is more common and dominant
The snails body plan curvature depends on the cleavage
pattern of the egg immediately after fertilization
Cross
and
Reciprocal cross
Figure 5.1
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Reciprocal cross
F1 mothers are Dd
The dominant allele,
D, caused ALL the F2
offspring to be dextral
Figure 5.1
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Figure 5.2a
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Figure 5.2b
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d gene products
cause egg cleavage
that promotes a lefthanded body plan
Figure 5.2b
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Figure 5.2c
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Dosage Compensation
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Barr
body
Figure 5.3
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One from its mother that carries an allele conferring white coat
color (Xb)
One from its father that carries an allele conferring black coat
color (XB)
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At an early stage of
embryonic development
Figure 5.4
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Heterozygous Hemizygous
female
male
Hemizygous
male
Origin
Slow G-6-PD
Fast G-6-PD
Direction of
migration
The Hypothesis
Figure 5.6
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The Data
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
All cells
1
Clones
10
Slow G-6-PD
Fast G-6-PD
Ronald G. Davidson, Harold M. Nitowsky, and Barton Childs. Demonstration of Two Populations of Cells in the Human Female Heterozygous for Glucose-6-Phosphate
Dehydrogenase Variants. PNAS. 50 (1963) f. 2, p. 484. Courtesy Harold M. Nitowsky. Reproduced with author permission.
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The heterozygous
woman produced
both types of
G-6-PD enzymes
All cells
1
Clones
3
Clones 2, 3, 5, 6, 9 & 10
expressed only the slow
type
Clones 4, 7 & 8 expressed
only the fast type
9 10
Slow G-6-PD
Fast G-6-PD
Ronald G. Davidson, Harold M. Nitowsky, and Barton Childs. Demonstration of Two Populations of Cells in the Human Female Heterozygous for Glucose-6-Phosphate
Dehydrogenase Variants. PNAS. 50 (1963) f. 2, p. 484. Courtesy Harold M. Nitowsky. Reproduced with author permission.
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Phenotype
Normal female
XX
Normal male
XY
X0
XXX
XXY
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Promotes
compaction
Prevents
compaction
Figure 5.7
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Initiation
Spreading
Maintenance
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Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Figure 5.8
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They include
Xist
Pseudoautosomal genes
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Not both
The Igf-2 gene encodes a growth hormone called insulinlike growth factor 2
Figure 5.9
Normal Size
Dwarf
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Female mouse
transmits
transcriptionally
inactive alleles
Figure 5.10
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It may involve
A single gene
A part of a chromosome
An entire chromosome
Even all the chromosomes from one parent
Not both
Methylation is
removed in gamete
forming cells
Figure 5.11
Methylation in male
gamete cells only
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PWS is characterized by
AS is characterized by
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Deletion
inherited
from
mother
Figure 5.12
Deletion
inherited
from
father
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5.4 EXTRANUCLEAR
INHERITANCE
Extranuclear inheritance refers to inheritance
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These proteins are made in the cytoplasm, then transported into the
mitochondria
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tRNAPhe
tRNAPro
12S rRNA
tRNAVal
tRNAThr
tRNAGlu
16S rRNA
tRNALeu
tRNAIle
tRNAGln
tRNAMet
tRNALeu
tRNASer
tRNAHis
tRNATrp
tRNAAla
tRNAAsn
tRNACys
tRNATyr
tRNAArg
tRNAGly
tRNASer
Figure 5.14
tRNAAsp tRNALys
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Maternal Inheritance
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Figure 5.15
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Figure 5.16
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These include
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Figure 5.17
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