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Learning Objectives
The enzyme
chymotrypsin is
shown with the bound
substrate in red.
Enzymes affect reaction rates, not equilibria.
E + S ES EP E + P
The free energy of the product (P) is less than the free energy
of the reactant (S), so ∆ G’o is negative and the equilibrium
favors the formation of P.
A favorable equilibrium does not mean that the S P
conversion will occur at a detectable rate. The rate of a
reaction is dependent on an entirely different parameter.
Energy barrier
between S and P
E + S ES EP E + P
ES and EP are reaction intermediates, and occupy valleys in
the reaction coordinate diagram.