Beruflich Dokumente
Kultur Dokumente
chalee
Outline
History
Definition
Basic Concepts
Types of Hypersensitivity
> Characteristics
> Components and Cells
> Process and Mechanism
> Common Diseases
History
Hypersensitivity reactions
> over reaction of the immune system to
harmless environmental antigens
> are harmful antigen-specific immune
Allergen
Atopy
Type I
IMMEDIATE HYPERSENSITIVITY
Allergen
Primary
Individual
Generation
IgE
Adhesion
Secondary
Bradykinin Leukotrienes
PAF
Prostaglandin D2
Skin
Respiratory tract
Digestive tract
TYPE II HYPERSENSITIVITY
ANTIBODY MEDIATED IMMUNITY
TYPE II DISEASES
Activate complement
Opsonic phagocytosis NK , phagocyte
Stimulate / block
ADCC
Antigen/Antibody Complexes
Where do they go?
Soluble antigen
Body
Antibody
Immune complex
C3a,C5a,C3b
Platelets
Infiltration of neutrophils
Tissue injury
Bleeding
Edema
Induce
Antigen
T cell
(CD4+,CD8+)
CD4+Release
T cell
Secondary
contact
Primed T cell
CD8+
T cell
Cytokines
IL-2
TNF-
INF-
TF
MCF
MIF
MAF
SRF
Infiltration of
monocyte and M
Proliferation of T cell
Exudation and edema
Cytotoxicity
Ascaris
Onchocerca
Toxoplasma
Enterobious
Enterobious
Plasmodium
Trichuris
Hookworm
Schistosome
Trypanosoma
Leishmania
Taenia
Wuchereria
Soluble antigen
Body
Antibody
Immune complex
C3a,C5a,C3b
Platelets
Infiltration of neutrophils
Tissue injury
Bleeding
Edema