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Risk Factors
Uncontrollable
Sex
Hereditary
Race
Age
Controllable
High blood
pressure
High blood
cholesterol
Smoking
Physical activity
Obesity
Diabetes
Stress and anger
Mechanism of Action
Atherosclerosis is associated with deposits of cholesterol which
Stage I
Monocyte adhesion/migration
Stage II
Foam cells (lipid containing
macrophages) in intima
Stage III
Appearance of extracellular lipid
Stage IV
Core formation
(extracellular lipid coalescing into the center
of the plaque)
Stage VI
Thrombosis
Stage V
Fibrous Cap and Core formation
(fully formed lipid core and well developed cap of
fibrous tissue seperating the core from the
lumen)
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Coronary
Angiography
Narrow in
g in
coronaries
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ec
Stress
Test
ea
rt
Electrocardiogram
show s
es
to
h
es
blo
od
su
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me
asu
r
of
es
Sit
electrical
me
a
Malek AM et al (1999)
Other Test
Blood tests: used to evaluate kidney and thyroid
hearts movement
Ejection fraction (EF): determines how well your
Drug Therapies
Statins
Inhibit
enzyme HMG-
CoA reductase.
Side
effects
can
include myositis
inflammation
of
or
the
muscles,
joint
pain,
stomach
upset,
and
liver damage.
Drug Therapies
Niacin (Nicotinic Acid)
Increase HDL, lower fatty acid released in blood
Side effects may include redness or flushing of the skin , stomach
into blood.
Liver produces more bile to replace it so liver use LDL cholesterol
in the blood.
Drug Therapies
Cholesterol absorption inhibitors
The medication ezetimibe (Zetia) limits how much dietary
Drug Therapies
Fibric acid derivatives (fibrates)
Effective at lowering triglyceride levels, and moderately
Treatment
Many people are able to manage coronary artery
Treatment (continued)
1. Stenting
a stent is introduced into a blood vessel on a balloon
Treatment (continued)
2. Angioplasty
artery wall
once plaque has been compressed and the artery has been
Treatment (continued)
3. Bypass surgery
healthy blood vessel is removed from leg, arm or chest
blood vessel is used to create new blood flow path in your heart
the bypass graft enables blood to reach your heart by flowing
around
(bypassing) the
blocked portion
of the diseased
artery. The
increased blood
flow reduces
angina and the
risk of heart
attack.
Prevention
Get regular medical checkups.
Control your blood pressure.
Check your cholesterol.
Dont smoke.
Exercise regularly.
Maintain a healthy weight.
Eat a heart-healthy diet.
Manage stress
Citations
1.
2.
Clark, John A Visual Guide to the Human Body Barnes & Noble
Books, 2001
3.
4.
5.
6.
www.Guidant.com
7.
www.Webmd.com
8.
www.Spotlighthealth.com
9.
Mayoclinic.com
10. Americanheart.org