Beruflich Dokumente
Kultur Dokumente
AliceMa,M.D.
UniversityofNorthCarolinaChapelHill
DivisionofHematology
August26,2004
Coagulationmadeeasy
ThePTTPathway
ThePTPathway
Coagulationmadeeasy
ThePTTPathway
ThePTPathway
Coagulationmadeeasy
ThePTTPathway
ThePTPathway
Coagulationmadeeasy
ThePTTPathway
ThePTPathway
V
X
Prothrombin
Thrombin
Coagulationmadeeasy
ThePTTPathway
ThePTPathway
V
X
Prothrombin
Thrombin
Fibrinogen
Fibrin
CoagulationmadeeasythePT
PT has one less letter than PTT,
and PT values are shorter than
PTT values, because the
pathway is shorter. It means
that the PT pathway is also
shorter and this is lucky, so the
lucky PT pathway uses lucky
factor 7 to activate factor X
Prothrombin
ThePTPathway
7
V
X
Thrombin
Fibrinogen
Fibrin
CoagulationmadeeasytheaPTT
ThePTTPathway
XII
XI
IX
VIII
Prothrombin
X
Thrombin
Fibrinogen
Fibrin
CoagulationmadeeasytheaPTT
ThePTTPathway
Prothrombin
X
Thrombin
Fibrinogen
Fibrin
CoagulationmadeeasytheaPTT
ThePTTPathway
Twelve
Eleven
Nine
Eight
Ten
Prothrombin
X
Thrombin
Fibrinogen
Fibrin
CoagMadeEasy:PTandPTTbothProlonged
ThePTTPathway
ThePTPathway
V
X
Prothrombin(II)
Fibrinogen
CoagMadeEasy:OnlyPTProlonged
7
Deficiency of Factor VII will prolong the PT but not the PTT
CoagMadeEasy:OnlyPTTProlonged
Twelve
Eleven
Nine
Eight
Ten
Whatmattersclinically
XII
XI
IX
VIII
VII
X
V
Thrombin
Fibrinogen
DeficienciesoffactorXI,IX,
VIII,VII.X,V,
prothrombinandfibrinogen
areclinicallysignificant.
Inhibitorsofthesefactors
areclinicallysignificant.
DeficiencyofFactorXII,
andthepresenceofthe
lupusanticoagulantarenot.
Fibrin
CoagulationMadeEasyTheMixingStudy
Usefultodifferentiateetiologiesofprolonged
clottinginacoagulationassay.
Patientsplasmaismixed50:50withnormal
plasma.Coagulationassayisrepeated.
Ifsubstantialcorrectionisnotedaftermix,
suspectclottingfactordeficiency.
Ifnoorminimalcorrectionseen,suspect
inhibitor.