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Mitochondrial Disease
Any disease involving the electron
transport chain
Early vs late-onset
www.umdf.org (http://www.umdf.org/site/c.8qKOJ0MvF7LUG/b.7929671/k.BDF0/Home.htm )
Xander Brooks, Courtesy of Dr. Shane O.P. Brooks, D.O. (father)
Indirect Effects
Mutations in accessory proteins leads to malfunction of the
complexes, secondary to the loss of function of the
supporting proteins
severe mtDNA mutations produce non-viable offspring,
leading to an early termination of pregnancy
Subcomplex Formation
Indirect Effects
Mutations in accessory proteins leads to
malfunction of the complexes, secondary to the
loss of function of the supporting proteins
Indirect Effects
Mutations in accessory proteins leads to
malfunction of the complexes, secondary to the
loss of function of the supporting proteins
Indirect Effects
Mutations in accessory proteins leads to
malfunction of the complexes, secondary to the
loss of function of the supporting proteins
Conclusion/Future Implications
Mutations in nDNA and mtDNA lead to
poor complex formation
http://mitochondrialdiseases.org/related-diseases/