Beruflich Dokumente
Kultur Dokumente
(Leukocytes)
Figure 4
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GRANULOPOIESIS
Granulopoiesis (or granulocytopoiesis) is
hematopoiesis of granulocytes. The blood
granulocytes and monocytes are formed in
the bone marrow from a common precursor
cell (figure 5).
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Figure 5
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2. Phagocytosis
In neutrophilsm;
H2O2 reacts with myeloperoxidase to kill
bacteria;
Activated oxygen may also be involves a
fall in pH within phagocytic vacuoles into
which lysosomal anzymes are released.
Lactoferrin an iron binding protein present
in neutrophil granules is bacteriostatic by
depriving bacteria of iron.
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In the oxygen-independent
Although more than two dozen factors
have been implicated in control of the
macrophages response to inflammation,
five of these are believed to play dominant
roles.
They are consist of :
1. tumor necrosis factor (TNF),
2. interleukin-1 (IL-1),
3. granulocyte-monocyte colony stimulating factor
(GM-CSF),
4. granulocyte colony stimulating factor (G-SCF),
5. monocyte colony stimulating factor (M-CSF).
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