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Development of the Vertebrate

Body Plan
Thomas A. Marino, Ph.D.
Department of Anatomy and Cell Biology.
Temple University School of Medicine

DEVELOPMENT OF THE
VERTEBRATE BODY PLAN
Early Development
1. Development of Ectoderm
A. Neural Tube
B. Surface Ectoderm
2. Development of Endoderm
A. G.I. Tract
B. Respiratory Tree
C. Pharynx
3. Development of Mesoderm
A. Paraxial
B. Intermediate
C. Lateral

Summary of Week 2
Trophoblast

Cytotrophoblast
Syncytiotrophoblast
Embryonic Ectoderm
Embryonic
Mesoderm
Embryonic
Mesoderm
Epiblast
Extraembryonic
mesoderm
Primitive
Streak
Notochordal
Process
Epiblast
Notochord
Embryonic
Endoderm
Amnioblasts

Blastocyst

Inner Cell
Mass
Hypoblast

Extraembryonic

Yolk Sac

Trilaminar Embryo

Ectoderm

mesoderm

Notochord

Endoderm

Trilaminar Embryo
paraxialmesoderm
mesoderm
paraxial

intermediate mesoderm
lateral mesoderm

Ectoderm
Yolk Sac

Cut edge of
Amnion

Primitive
Node

Primitive Streak

Ectoderm

Epiblast

Primitive Streak

Primitive
Node

Ectoderm

Lack of BMP-4
Presence of:
Noggin
Forebrain
Chordin
Midbrain
Follistatin
WNT-4a
Hindbrain
FGF
Spinal cord

Notochord

Ectoderm

Notochord
Neural
Plate

Ectoderm

Notochord
Neural
Plate

Ectoderm

Oral
Plate
Prechordal
Plate
Notochord
Neural
Plate

Ectoderm
Neural
Groove
Neural
Plate

Ectoderm

Neural Groove
Neural Fold
Somites

Day 20

Ectoderm

Somites
Pericardial
Bulge
Neural Tube

Ectoderm
Cranial Neuropore
Pericardial Bulge

Somites

Caudal Neuropore

UNSW Embryology

Ectoderm
The role of the cytoskeleton in the development of the neural tube
Actin filaments

Ectoderm
The role of the cytoskeleton in the development of the neural tube
Microtubules

Development of the Neural


Tube

Development of the Neural


Tube

Development of the Neural


Tube

Development of the Neural


Tube

Development of the Neural Tube


Surface Ectoderm

Neural Crest Cells

Neural Tube

Development of the Neural Tube

Development of the Neural Tube

Lateral Body Folding

Lateral Body Folding

Lateral Body Folding

Lateral Body Folding

Lateral Body Folding

Lateral Body Folding

Lateral Body Folding

Lateral Body Folding

UNSW Embryology

Lateral Body Folding


Surface ectoderm
Amniotic
Cavity

Body
Cavity

Chorionic
Cavity

Paraxial mesoderm
Neural Tube

Intemediate
mesoderm

Surface Ectoderm
cranial and sensory
ganglia and nerves,
epidermis, hir, nails,
medulla of adrenal
cutaneous and
gland,
mammary glands,
anterior pituitary gland, Neural pigment cells,
enamel of teeth, inner Crest: branchial arch
cartilages,
ear, and lens
head mesenchyme
Ectoderm

mesoderm
Neural Tube
central nervous
system, retina,
pineal body,
posterior pituitary

Endoderm

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