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ories
Zulfiayu
S1 Farmasi UNG Mei 2012
History
In writings of early Egyptians, Greeks
and Romans.
Hippocrates : administration to very
young and very old
Pengertian
RPS : solid dosage forms of various weights
and shapes, usually medicated, for insertion
into the rectum, vagina or the urethra.
DOM : solid dosage forms intended for
administration via any several body orifices,
namely rectum, the vagina, or the urethra.
Scoville : conveniently shaped medicated
solids intended for insertion into one of the
body orifices other than the oral cavity/the
agents for use in the rectum, vagina, or
urethra
Pengertian
Pengertian
Local action
Hemorrhoids and pruritus ani :
anestetic action, astringent effect,
soothing properties
Vaginal suppositories of endocrine
drugs : treatment of vulvar n vaginal
conditions, vaginitis
Systemic action
Analgesic
Antispasmodic
Types
Macam Suppositoria
2. S.vaginal(ovula, pessary), berbentuk
bola lonjong spt kerucut, digunakan lwt
vagina, 3-5 g, FI III 3-6 g, umumnya 5 g.
larger than rectal s.,wedge shaped,
globular, oviform, or rod-shape
Macam Suppositoria
3. S.uretra (bacilla, bougies) digunakan
lwt uretra, bentuk panjang, 7-14 cm.
RPS : d:5mm, length 50 mm(f) 125
mm(m),
2 g (f), 4 g (m)
Long, thin, pencil-shaped and pointed
at one end to vacilitate insertion.
Keuntungan Suppositoria
1. Menghindari iritasi pd lambung
2. Menghindari kerusakan obat oleh enzim
pencernaan dan asam lambung
3. Rapidly pass directly into the venous
circulation
4. Drug cannot be tolerated by mouth,
either because the patient becomes
nauseated or vomits, or where, for some
other reason, oral is contraindicated.
5. Sustained action over a long period of
time is indicated
Faktor yg mempengaruhi
absorpsi obat per rektal
Faktor fisiologis
(anorectal
physiology)
The rectum is about
150 mm in length,
small amount of
fluid of low buffering
capacity. Rectal
epithelium is lipoidal
Rectal Suppositories
Rectal Suppositories
1. Wash your hand thoroughly with a soap and water
2. If the suppository is soft, hold it under cool water
to harden it before removing the wrapper.
3. Remove the wrapper, if present.
4. If you were told to take half of a suppository, cut it
lengthwise with a clean, single-edge razor blade.
5. Put on a finger cot or disposable glove, if desired
6. Lubricate the suppository tip with a water-soluble
lubricant such as K-Y Jelly, not petroleum jelly
(vaseline). If you do not have this lubricant,
moisten your rectal area with cool tap water.
Rectal Suppositories
7. Lie on your side with your lower leg straightened
out and your upper leg bent forward toward your
stomach.
8. Lift upper buttock to expose the rectal area.
9. Insert the suppository, pointed end first, with your
finger until it passes the muskular sphincter of the
rectum, about to 1 inch in infants and 1 inch in
adults. If not inserted pst this sphincter, the
suppository may pop out.
10. Hold buttocks together for a few seconds
11.Remain lying down for about 15 minutes to avoid
having the suppository come out.
12.Discard used materials and wash your hands
thoroughly.
Preparation
1. Rolled (hand-shaping)
2. Molding (fusion)
3. Cold compression
Mencetak
tuang-fusion
or
melt
molding
Pertama-tama bahan basis dilelehkan, sebaiknya
diatas penangas air atau penangas uap untuk
menghindari pemanasan setempat yang
berlebihan, kemudian bahan-bahan aktif
diemulsikan atau disuspensikan kedalamnya.
Akhirnya massa dituang kedalam cetakan logam
yang telah didinginkan, yang umumnya dilapisi
krom atau nikel
si h
a
k
a
Terim
Pustaka
FI III/IV
DOM, 834
Scoville, 367
Lachman
RPS, 1609