tate 3. Example of Split/mixed Insulin Regimen* Morning (Before breaitfast): 16 NFH Before dinner or at bedtime: & MPH Sliding seale requiar or rapid-acting dove: Hood Glucose Concentration (mgfdl) (mmol/L) Breakfast: Dinner 50 (2.8) 6 4 50 to 100 (2.8 t0 5.6) rT 5 100 te 150 (5.6 to 6.3) & & 150 to 200 (6.3 to 11.1) 8 Tr 200 te 250 (11.1 10 5 250 to 300 (13.5 WW a »300 (167) 12 we For 240g child cova cea dha De 2 fed maniber of carbesrpdeaar ana per mcal (for mead aad fer aracia|. NVR=iruenllproamiar HagerkorsTable 1. Risk of Developing Type 1 Diabetes for Individuals Who Have an Affected Relative Sibling Risk ‘Overall So Identical twin <50% HLA identical 15% HLA identical 5% HLA nonidentical 1% Offspring Risk ‘(Overall 50 Father who has IDDM SM Mother who has IDDM 2% HLA=human leukocyre ancigen, [DM =insulin-dependent diabercs mneilirusTable 1. Subtypes of MODY Moby MODY? MoDY3 Mopys —-MODYS MoDYs — MODYX Gent os Mk Wy 1 TeengQl3 2 Vakrown Gane ENE — Ghuookinase HNFle DRI HNFAB NawroD1 Unknown! heterogencous? Distribution Rae 63 A Rare Vakrosn Rare 145% (Gof MODY fans) ‘Ageatdagnsis Postpubrial Cithood — Potpabertal Exly Pasipubrl Exly Heteogenanas autho aduthood Primary defect Pancreas’ = Pancreay Pancreas! Pancreas) Pancreas! Pancreas) Pancreas! liv ler ——_‘idnefther? ober? ——_‘kidnefthar? ober? ———_—eleogenos! Associated features - Reduced Reduced tubular - Glomerulocystic - - tinh wight reabsoionofgucose lida diese Decreased cose Genial malformations threshold for eovura Sovriyofdabees Sows, Mid ‘Soree Mi? Milt Unknown Mild beteropncos? Complicationsofdiabeies Frequent Rare Frequent Rat Ran Unknove Unknown * Different distributions in different populations, HNF = hepatocyte nuclear factor, IPF= insulin promoter factor,