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(a): Left smells like menthol and right smells like green bell peppers.
(b): Two molecules that dont have a smell: methane and carbon monoxide. Never evolved
sensitivity to these: not too much fossil fuel burning back in the day.
Tertiary-butyl mercaptan (smells like rotten eggs) added by the gas company to natural gas.
Not because these are too smallanisole and benzaldehyde are odorants (top, right).
Structure is kingR-carvone and S-carvone (mirror images) have completely different smells.
Compared with other mammals, humans dont smell very well (good?)
The olfactory bulb
is proportionally
smaller in humans
than other
animals.
Humans have smaller olfactory bulbs and fewer receptors than rats and dogs
(despite our larger size).
Olfactory neuron is
composed of several
parts:
The cell is bipolar in
nature with a
centrally located cell
body and an
axon extending in
one direction toward
the brain and a
dendrite that
projects toward
the
Bowmans gland makes mucus: odorants are
dissolved in the mucus and can then be detected
by olfactory cilia.
OSN 2
OSN 3
Odorant 2
Odorant 3
Olfactory Physiology
Limbic system: The encompassing group of neural
structures that includes the olfactory cortex, the
amygdala, the hippocampus, the piriform cortex, and
the entorhinal cortex.
Involved in many aspects of emotion and memory.
Olfaction is unique among the senses for its direct
and intimate connection to the limbic system.
Olfactions unique connection to the limbic system
explains why scents tend to have such strong emotion
associations.
Another example
of shape-pattern theory.
From Chemicals
to Smells
More complex structure (blue triangle bound to orange square).
It can bind to either triangle or square receptors of either color.
Size of the response will be a function of the best fit.
Blue-to-orange and orange-to-blue are not as good as
blue-to-blue or orange-to-orange. But more complex structure
gives a wider range of responses.
Odor mixtures
We rarely smell pure odorants. Rather, we smell mixtures.
How do we process the components in an odorant mixture?
Two possibilities:
Analysis: Example from auditory mixtures. Chord of three notes
can played together and we perceive them all, but we can
detect each individual note.
Synthesis: Example from color mixtures. Mixing red and green
lights results in yellow light, but we cannot separately perceive
the red and green in the yellow.
Odor imagery
Humans have little or no ability to conjure odor
images
We do not think in smell very well.
We do not imagine smells very welldreams
with olfactory sensations are very rare.
Adaptation
Sense of smell is essentially a change detector.
Examples: Walking into a bakery and can only smell
fresh bread for a few minutes.
Odor Hedonics
The liking dimension of odor perception, typically measured with scales pertaining to
an odorants perceived familiarity and intensity.
Rose smell
Fishy smell
Taste buds and taste receptor cellsnot on the surface of the papillae, but
on the sides.
Taste pore lets in saliva that has dissolved tastant molecules.
Taste cells (aka taste receptor cells) make up taste bud.
Microvilli: Slender projections on the tips of taste receptor cells that
extend into the taste pore and have sites that detect tastants.