Beruflich Dokumente
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the infiltration/replacement of
abnormal cells or tissue component
into the Bone marrow
fibrotic,granulomatous or neoplastic
cells
Premature release
of
immature cells from BM occurs
-resulting to Cytopenia
Pathology
NORMOCYTIC,NORMOCHROMIC
Peripheral blood
increased nonRBCs
Polychromatophilia,basophilic
stippling and reticulocytosis
blood film at 1000X magnification demonstrates a leukoerythroblastic blood picture with the presence of
precursor cells of the myeloid and erythroid lineage. In addition, anisocytosis, poikilocytosis, and
polychromasia can be seen.
*Courtesy of U. Woermann, MD, Division of Instructional Media, Institute for Medical Education, University
of Bern, Switzerland.
kidney function.
EPO
production
Low levels
iron, vitamin
B12 &folic
acid from
diet
accumulatio
n Uremic
toxins
Anemia
of
CKD
Hemodialysis
Frequent; blood
draws
;gastrointestinal
bleeding
high level of
inflammator
y cytokines
parathyroid
hormone &
spermine in
the plasma
Schematic representation of the mechanisms underlying anemia of CKD. Iron and EPO are
crucial for red blood cell production in the bone marrow.
serum
creatinine=
hematocrit=
degree of
shortening of
RBC survival
Chemistry
Moderately
Normocytic &
hypercellular;
normochromic,
Burr cells
Erythroid
w/ normal
hyperplasia
indices
some helmet
may be present
Hematology
cells
Bone marrow
fragments may
be present as a
result of uremia
Pathology
cardiovascular
complications
faster
progression
to kidney
failure
suboptimal
quality of
life