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Magnesium
Regulation
Magnesium (Mg2+) is the fourth most abundant
cation in the body. Thus, magnesium homeostasis
needs to be tightly regulated
This is facilitated by intestinal absorption and renal
excretion.
Magnesium absorption is dependent on two
concomitant pathways found in both in the
intestine and the kidneys: passive paracellular
transport via claudins facilitates bulk magnesium
absorption, whereas active transcellular pathways
mediate the fine-tuning of magnesium absorption.
Serum Magnesium
Normal serum Mg2+ = 1.4-2.2 mEq/L
Patients serum Mg2+: 2.0mEq/L
(normal)
Hypermagnesemia
Rare but can be seen with severe renal
insufficiency and parallel changes in
potassium excretion
Mg-containing antacids and laxatives can
produce toxic levels in patients with renal
failure
Excess intake in conjunction with TPN, or
rarely massive trauma, thermal injury, and
severe acidosis, may be associated with
symptomatic hypermagnesemia
Clinical Manifestations
Symptoms
Nausea and vomiting
Neuromuscular dysfunction with weakness,
lethargy, and hyporeflexia
Impaired cardiac conduction leading to
hypotension and arrest
ECG changes: similar to hyperkalemia
PR interval
widened QRS complex
elevated T waves
Treatment
Eliminate exogenous sources of
magnesium
Correct concurrent volume deficits
Correct acidosis if present
To manage acute symptoms: calcium
chloride (5 to 10 mL) is given to
immediately antagonize the
cardiovascular effect
If elevated levels or symptoms
persist: hemodialysis
Hypomagnesemia
Common problem in hospitalized patients,
particularly in the critically ill
Kidney: primarily responsible for Mg homeostasis
o Regulation by Ca/Mg receptors on the renal
tubular cells that respond to serum Mg
concentrations
May result from alterations of intake, renal
excretion, and pathologic losses
Poor intake: starvation, alcoholism, prolonged IV
fluid therapy, and TPN with inadequate
supplementation of magnesium.
Clinical Manifestations
Hyperactive reflexes
Muscle tremors o Tetany
(+) Chvosteks and Trousseaus signs
Severe deficiencies can lead to delirium and
seizures
ECG changes
Prolonged QT and PR intervals
ST-segment depression
Arrhythmias
Treatment
If asymptomatic and mild: Oral
For those with severe deficits (<1.0 mEq/L) or those
who are symptomatic: 1 to 2 g of Mg2SO4 IV over
15 minutes
Under ECG monitoring, it may be given over 2
minutes to correct torsades de pointes
Caution should be taken when giving large amounts
of Mg toxicity may develop
The simultaneous administration of calcium
gluconate will counteract the adverse side effects of
a rapidly rising magnesium level and correct
hypocalcemia, which is frequently associated with
hypomagnesemia.