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Overview
Background
History, classification and controversies!
Complications
CVD, CKD progression, other complications
CKD Management
Management of CKD: role of primary and secondary care
Referral guidelines
Who to screen and when to refer
Discussion
Overview
Background
History of CKD
Classification
Model of CKD
History of CKD
Chronic renal failure/impairment
NKF/KDOQI CKD guidelines
Terminology
Definition/classification
MDRD eGFR
Association of level of kidney function with
complications
Risk factors for progression
[AJKD Suppl. Feb 2002]
CKD Classification
www.NICE.org.uk/guidance/CG73
Model of CKD
Overview
Background
Complications of CKD
Cardiovascular disease
Hypertension
Anaemia
Bone-mineral metabolism
Poor nutritional and functional status
Progression of CKD
Complications of CKD
Complications of CKD
Hypertension
80% HD patients, 50%
PD patients
CKD progression
associated with HTN
HTN associated with
level of eGFR
Complications of CKD
Anaemia
NHANES III
Complications of CKD
Cardiovascular disease
Overview
Background
Complications of CKD
Management of CKD
Diagnosis
Managing complications
Progression of CKD
Pre-ERF planning
Primary vs. secondary care management
Diagnosis
CKD classification does not mandate a
diagnosis
Generic management of CKD
Disease-specific management
Percentage of patients
Diabetes
24.8
Glomerulonephritis
13.3
Pyelonephritis
7.1
Hypertension
7.0
7.2
6.9
Other
16.3
Uncertain
17.3
CKD Progression
What is significant progression?
What risk factors are associated with
progression?
Why is progressive CKD important?
CKD Progression
What is significant progression?
Most patients with CKD will not progress to
ERF
How many patients in the UK have CKD?
How many start RRT each year?
CKD Progression
What is significant progression?
Most patients with CKD will not progress to
ERF
How many patients in the UK have CKD?
4.94 million (8% of 61.8M)
CKD Progression
What is significant progression?
CKD Progression
What is significant progression?
eGFR decline >5ml/min/1.73m/year
Or >10ml/min/1.73m in 5 years
CKD Progression
What is significant progression?
eGFR decline >5ml/min/1.73m/year
Or >10ml/min/1.73m in 5 years
Cardiovascular
disease
Smoking
Ethnicity
NSAIDS
CKD Progression
What is significant progression?
What risk factors are associated with
progression?
Why is progressive CKD important?
Overview
Background
Complications of CKD
Management of CKD
Diagnosis
Managing complications
Progression of CKD
Pre-ERF planning
Primary vs. secondary care management
(Dialysis) planning
Consequences of late presentation
Rate of late presentation
Planning
All children, young people and adults approaching established renal
failure are to receive timely preparation for renal replacement
therapy so the complications and progression of their disease are
minimised, and their choice of clinically appropriate treatment
options is maximised
People with established renal failure receive timely evaluation of their
progress, information about the choices available to them, and for
those near the end of life a jointly agreed palliative care plan, built
around their individual needs and preferences
Planning
Dialysis
Haemodialysis (hospital, satellite, home)
Peritoneal dialysis (CAPD, APD)
Transplantation
Deceased-donor transplant
Living-donor transplant (including pre-emptive)
Other options (e.g. kidney-pancreas, paired-exchange,
desensitisation)
Conservative care
Overview
Background
Complications of CKD
Management of CKD
Diagnosis
Managing complications
Progression of CKD
Pre-ERF planning
Primary vs. secondary care management
CKD Management
Identification
(Renal) diagnosis
Progression
eGFR monitoring
BP control
ACE/ARB if appropriate
Anaemia management
Bone mineral metabolism
Nutrition
RRT planning/education
Identification
(Renal) diagnosis
Progression
eGFR monitoring
BP control
ACE/ARB if appropriate
Anaemia management
Bone mineral metabolism
Nutrition
RRT planning/education
Primary care
Renal care
CKD 3
84.6%
1.5%
CKD 4
62.7%
25.1%
CKD 5
30.0%
61.1%
CKD 1:
QoF
The practice can produce a register of patients aged 18 years and over with CKD (US
National Kidney Foundation: Stage 3 to 5 CKD).
CKD 2:
The percentage of patients on the CKD register whose notes have a record of blood
pressure in the previous 15 months.
CKD 3:
The percentage of patients on the CKD register in whom the last blood pressure reading,
measured in the previous 15 months, is 140/85 or less
CKD 5:
The percentage of patients on the CKD register with hypertension and proteinuria who are
treated with an angiotensin converting enzyme inhibitor (ACE-I) or angiotensin receptor
blocker (ARB) (unless a contraindication or side effects are recorded).
CKD 6:
The percentage of patients on the CKD register whose notes have a record of a urine
albumin: creatinine ratio (or protein: creatinine ratio) test in the previous 15 months
Overview
Background
Complications of CKD
Management of CKD
Referral guidelines
Who should be tested?
Frequency of testing
Who should be referred?
What information is required?
Overview
Background
Complications of CKD
Management of CKD
Referral guidelines
Who should be tested?
Frequency of testing
Who should be referred?
What information is required?
Overview
Background
Complications of CKD
Management of CKD
Referral guidelines
Who should be tested?
Frequency of testing
Who should be referred?
What information is required?
Considerations
Consider discussing management issues with a specialist by letter, email or telephone in cases where it may not be necessary for the
person with CKD to be seen by the specialist.
Once referral has been made and a plan jointly agreed, it may be
possible for routine follow-up to take place at the patients GP
surgery rather than in a specialist clinic. If this is the case, criteria for
future referral or re-referral should be specified.
Take into account the individuals wishes and comorbidities when
considering referral.
People with CKD and renal outflow obstruction should be referred to
urological services, unless urgent medical intervention is required,
e.g. for treatment of hyperkalaemia, severe uraemia, acidosis or
fluid overload.
Overview
Background
Complications of CKD
Management of CKD
Referral guidelines
Who should be tested?
Frequency of testing
Who should be referred?
What information is required?
Risk of progression
uACR/PCR
Summary