Homeostasis Regulation

Debby Mirani Lubis, MD,

M.Biomed
Department of Physiology
Faculty of Medicine UMSU

Sub content
Component of homeostasis
regulation
Negative and positive feedback

Introduction
Human body system organ
tissue cells
Cells different function work
together maintenance internal
environtment
Homeostasis The many
processes the body controls its
internal environment

 Internal & external environtments

changing adjustments stay at or
near the set point (the normal level
or range).
Homeostatic regulation The
adjusting of systems within a cell
Homeostasis a dynamic
equilibrium rather than a constant,
unchanging state

Components of homeostasis
1.
2.
3.
4.
5.

Variable : the factors being regulated (T, BG)

Stimulus : input
Receptor : pick up the stimulus
Afferent pathway : carries information
Control center: access, analyze & compare to
the set point, determines the response
6. Set point : the value that must be maintained
7. Efferent pathway : carries response
8. Effector : carries out the action

Feedback regulation
Stimulus internal environment
responses changes internal
environment new stimulus
Feedback regulation self-adjusting
mechanism
Feedback regulation new
stimulus original stimulus

Components of feedback
system
Reseptor monitor changes
Control center generates output
commands
Effectors produces response

Positive & negative

feedback

Ex: original stimulus = A, new stimulus = B

Negative feedback B A <<<
Positive feedback B A >>>
Endocrine system mayor regulator
hormones
Hormone A response hormone B
Hormone B <<< hormone A negative
feedback
Hormone B >>> hormone A positive

Negative feedback
Most common
Provide stability

Positive feedback
Less common
Positive feedback speed up the
direction of change.
Example: estrogen LH

Examples of homeostasis
The regulation of the amounts of water and
minerals in the body osmoregulation
primarily in the kidneys.
The removal of metabolic waste
excretion by the excretory organs the
kidneys and lungs.
The regulation of body temperature the
skin.
The regulation of blood glucose level the
liver & pancreas.

Homeostatic
Processes

Osmoregulatio
n (also known
as excretions)

excess water,
salts, and urea
expelled from
body

Hormones
and Other
Messenger
s

Tissues, Organs and

Organ Systems
Involved

Antidiuretic
hormone
(ADH),
aldosterone,
angiotensin
II, carbon
dioxide

Kidneys, urinary
bladder, ureters,
urethra (urinary
system), pituitary gland
(endocrine system),
lungs (respiratory
system)

Sweating,
shivering,
dilation/constrict
ion of blood
vessels at skin
Thermoregulat
Nerve
surface,
ion
Impulses
insulation by
adipose tissue,
breakdown of
adipose tissue to

Skeletal muscle
(muscular system),
nerves (nervous
system), blood vessels
(cardiovascular system),
skin and adipose tissue
(integumentary
system), hypothalamus
(endocrine system)