IMMUNIZATION IN

CONGENITAL HEART
DISEASE
Liza Maria Rouly

CONGENITAL HEART
DISEASE
Asplenia or polysplenia (functional
hyposplenia)
DiGeorge syndrome (T-cell deficiency)
Complex single ventricle or shuntdependent lesions (eg, post-Norwood
procedure): increased risk of deterioration
or collapse

3 Main Reasons of
Asplenia

Surgical removal (eg, post-trauma)

Disease (eg, sickle cell disease,

thalassaemia)

Congenital asplenia or polysplenia (eg,

with congenital heart disease)

Asplenic Risk of Bacteraemia

Immunisation of asplenic individuals

No vaccines are contraindicated

Di George Syndrome

DiGeorge syndrome (T-cell deficiency)

Live vaccines are contraindicated

T-cell deficiency
IVIG replacement therapy Passive
protection against most vaccinepreventable infections.

Influenza
Regardless of their age
After first time two vaccine doses at least
four weeks apart, and one dose annually
after that.

T-cell deficiency
The efficacy of any vaccine depends on the
degree of immune deficiency.
Recommended: PCV13 and 23PPV,
meningococcal and influenza
Contraindicated: BCG, MMR, varicella,
rotavirus