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DRUG STUDY

Source:

Bacteria
Isolated

Antibiotic
Sensitive to:

July 15

Name of the
Drug

Dosage
Frequency
Preparation

Classificati
on

Mechanisms of
Action

Adverse
Reactions

Nursing
Consideration
s

Wound

Staphyloccus
aureus, heavy
growth

Oxacillin,
Levox,
Moxiflox,
Ciprofloxacin,
Clindamycin,
Coamox,
Timentin

Clindamycin

Dose: 600mg
Route: IV via
soluset
Frequency:
Every 8 Hours

Antibiotics

It blocks the
transpeptidation
or translocation
reactions of
susceptible
organisms
resulting to
stunted cell
growth.

Diarrhea,
nausea,
vomiting,
abdominal
pain;
erythema
multiform,
contact
dermatitis,
exfoliative
and
vesiculous
dermatitis,
urticaria;
eosinophili
a; local
irritation,
thromboph
loebitis.
Potentiall
y
Fatal:Gas
ping
syndrome
(neonates);
pseudome
mbranous
colitis.

Assessed for
any signs of
super infection
(furry
overgrowth on
the tongue
and vaginal or
anal itching or
discharge.
Instruct the
patient to
report this
signs to the
health care
provider

DRUG STUDY
Source:

Bacteria
Isolated

Antibiotic
Sensitive to:

July 15

Name of the
Drug

Dosage
Frequency
Preparation

Classification

Mechanisms
of Action

Adverse
Reactions

Nursing
Consideration
s

Wound

Staphyloccus
aureus, heavy
growth

Oxacillin,
Levox,
Moxiflox,
Ciprofloxacin,
Clindamycin,
Coamox,
Timentin

Levofloxacin
(levox)

Dose:500mg
Route: IV
Frequency:
Every 8hours

Anti-Infectives
& Antiseptics /
Quinolones

Levofloxacin
exerts
antibacterial
action by
inhibiting
bacterial
topoisomerase
IV and DNA
gyrase, the
enzymes
required for
DNA
replication,
transcription
repair and
recombination.
It has in vitro
activity
against a wide
range of gramnegative and
gram-positive
microorganism
s

Oral/IV:
Nausea,
diarrhea,
constipatio
n,
headache,
insomnia,
inj site
reactions
(IV).
Ophthalmi
c: Transient
decrease in
vision,
ocular
burning,
ocular pain
or
discomfort,
foreign
body
sensation,
headache,
fever,
pharyngitis
,
photophobi
a.
Potentiall
y
Fatal:Ana
phylaxis.

Assessed for
any signs of
dizziness and
drowsiness
Instruct
patient to
avoid driving
or other
activities
requiring
alertness

DRUG STUDY
Source:

Bacteria
Isolated

Antibiotic
Sensitive to:

July 15

Name of the
Drug

Dosage
Frequency
Preparation

Classification

Wound

Staphyloccus
aureus, heavy
growth

Oxacillin,
Levox,
Moxiflox,
Ciprofloxacin,
Clindamycin,
Coamox,
Timentin

Oxacillin
(Wydox)

Dose:2gms
Route: IV
Frequency:
Every 6 hours

AntiInfectives &
Antiseptics /
Penicillins

Mechanisms
of Action

Adverse
Reactions

Nursing
Consideration
s

Inhibits cell
wall
biosynthesis
by binding to
one or more of
the penicillinbinding
proteins,
which in turn
inhibits the
final
transpeptidati
on step of
peptidoglycan
synthesis in
bacterial cell
walls. Bacteria
eventually lyse
owing to
ongoing
activity of cell
wall autolytic
enzymes
(autolysins
and murein
hydrolases)
while cell wall
assembly is
arrested

Fever;
rash;
diarrhoea,
nausea,
vomiting;
agranulocy
tosis,
eosinophili
a,
leukopenia,
neutropeni
a,
thrombocy
topenia;
AST
increased,
hepatotoxi
city; acute
interstitial
nephritis,
haematuri
a; serum
sicknesslike
reactions.
Potentiall
y Fatal:
Anaphylaxi
s

Assessed for
any signs of
dizziness and
drowsiness
Instruct
patient to
avoid driving
or other
activities
requiring
alertness

DRUG STUDY
July 19

Name of
the Drug

Source:

Necrotic tissue
left leg, second
debridement

Linezoli
d

Bacteria
Isolated

Staphylococcus
intermediate,
moderate

Antibiotic
Sensitive
to:

Linezolid,
Vancomycin,
Coamox,
imipinem,
amikacin,
timentin

Dosage
Frequency
Preparation
Dose: 1gm
Route: IV
Frequency:
Every 8
hours

Classificatio
n
Antibiotics

Mechanisms of
Action
Linezolid is an
bacteriostatic
oxazolidinone,
Inhibiting
ribosomal
protein
synthesis. It is
active against
Grampositive
bacteria
including
vancomycinresistant
enterococci and
MRSA. It has
limited in-vitro
activity against
gram-negative
bacteria.

Adverse
Reactions
Diarrhea
(antibiotic
associated
colitis
reported),
headache,
nausea,
vomiting,
Constipation
abnormal
liver function
tests, fever,
vaginal and
oral
candidiasi
s,
skin rash,
pruritus,
dizziness,
insomnia,
anemia,
tongue
discoloration,
Tastedisturban
ce,

Nursing
Consideratio
ns
Assessed for
any signs of
super
infection
(furry
overgrowth
on the
tongue and
vaginal or
anal itching
or discharge,
loose or foul
smelling
stool or
allergy
Instruct the
patient to
report this
signs to the
health care
provider

DRUG STUDY
July 15

Source:

Bacteria
Isolated

Antibiotic
Sensitive to:

Wound

Staphyloccu
s aureus,
heavy
growth

Oxacillin,
Levox,
Moxiflox,
Ciprofloxaci
n,
Clindamycin
, Coamox,
Timentin

Name of
the Drug
Ertapenem

Dosage
Frequency
Preparation
Dose: 1gm
Route: IV
Frequency:
Every 8hours

Classificati
on
Antibiotics

Mechanisms
of Action
Ertapenem
acts similarly
to penicillins
by bacterial
cell wall
inhibition.

Adverse
Reactions

Nursing
Consideration
s

GI effects
frequently dry
mouth, taste
disturbances;
hypotension,
chest pain,
edema,
pharyngeal
discomfort,
dyspnea,
dizziness, sleep
disturbances,
confusion,
asthenia,
seizures,
vaginitis, raised
glucose;
Potentially
Fatal:Pseudome
mbranous colitis,
Stevens-Johnson
syndrome.

Assessed for
any signs of
super infection
(furry
overgrowth on
the tongue
and vaginal or
anal itching or
discharge,
loose or foul
smelling stool
or allergy
Instruct the
patient to
report this
signs to the
health care
provider

DRUG STUDY
July 23

Source:

Bacteria
Isolated

Antibiotic
Sensitive to:

Wound
discharge, left
medial thigh

Candida
Tropicalis
moderate
growth

Fluconazole,
Flucytosine,
Voriconazole,
amphotecerin
B

Name of
the Drug
Fluconazo
le

Dosage
Frequency
Preparation
Dose:
150mg
Route: PO
Frequency:
Once daily

Classificati
on

Mechanisms
of Action

Adverse
Reactions

Antifungals

inhibiting cell
membrane
formation of
susceptible
fungi

Nausea,
abdominal pain,
vomiting,
diarrhoea,
flatulence;
elevated liver
function values;
headache; rash,
exfoliative
dermatitis.
Rarely,
angioedema,
anaphylactic
reactions and
thrombocytopeni
a.
Potentially
Fatal:Hepatotox
icity; rarely
anaphylaxis;
Stevens-Johnson
syndrome.

Nursing
Consideration
s
Assessed for
any signs of
skin rash,
abdominal
pain, fever or
diarrhea.
Instruct the
patient to
report this
signs to the
health care
provider

DRUG STUDY
August 4

Name of
the Drug

Source:

Necrotic
tissue left
leg

Piperacillin
Tazobacta
m
(Tazocin)

Bacteria
Isolated

Pseudomon
as
aeroginosa

Amikacin,
pipperacilintazobactam,
tobramycin,
getamycin,
neteimicin

Antibiotic
Sensitive to:

Dosage
Frequency
Preparation
Dose:
2.25gms
Route: IV
Frequency:
Every 8
hours

Classificati
on
Antibiotics/
Penicillins

Mechanisms
of Action

Adverse
Reactions

Nursing
Consideration
s

Tazobactam is
a penicillanic
acid sulfone
derivative with
betalactamase
inhibitory
properties. In
combination,
tazobactam
enhances the
activity of
piperacillin
against betalactamaseproducing
bacteria

Diarrhea, skin
rashes,
occasionally
platelet
mediated
bleeding, rigors,
malaise,
ulcerative
stomatitis. Injsite reactions
such as pain,
erythema,
induration and
thrombophlebitis
.
Potentially
Fatal:Serious,
anaphylactic
reactions

Assessed for
any signs of
super infection
(furry
overgrowth on
the tongue
and vaginal or
anal itching or
discharge,
loose or foul
smelling stool
Instruct the
patient to
report this
signs to the
health care
provider