LTM EBM PEMICU 1

Etiologi
Bagaimana pengaruh klomifen sitrat
terhadap kista ovarium pada wanita
infertil?
P : Wanita infertil
I : Klomifen sitrat
C : Tidak diberi perlakuan, plasebo,
obat lain
O : Kista ovarium

Proses pencarian literatur

Pubmed : 1068 artikel
Jurnal terpilih : The use of
clomiphene citrates for ovulation
induction in women with functional
ovarian cyst
Alasan memilih jurnal:
Memiliki judul dan abstrak yang
menarik
dan
relevan
dengan
permasalahan yang perlu diselesaikan

ANALISIS PECOT
P : Wanita infertil di klinik infertilitas
Rumah Sakit Universitas Shatby
Maternity
E : Klomifen Sitrat
C : Plasebo
O : Tingkat persisten kista
T : Tidak diketahui

Wanita infertil di klinik infertilitas

Rumah Sakit Universitas
Shatby Maternity

60

Plasebo

Klomifen Sitrat
3
0

Kista persisten

Tidak

21

30

28

Penghitungan nilai P menggunakan

rumus Chi-Square
Kista persisten
Ya

KS

Kontrol

2
11

Tidak

21

28
49

30

30
60

E1
E2
E3
E4

:
:
:
:

(30*11/60)
(30*49/60)
(30*11/60)
(30*49/60)

= + + +
= 5,454546
df = 1

=
=
=
=

5,5
24,5
5,5
24,5

ANALISIS RAMBOMAN
R : 60 wanita dipilih dari klinik infertilitas Rumah
Sakit Universitas Shatby Maternity
Kriteria inklusi :
Patients were between 20 and 35 years old, BMI
C30, infertility duration 62 years. Anovulation was
documented by presumed mid-luteal (day 1923)
serum progesterone in previous cycle 63 ng/ml. All
patients had unilocular, clear content, thin walled
ovarian cyst with 65 cm diameter, persistent since
previous cycle on the third day of spontaneous or
induced withdrawal bleeding

Kriteria ekslusi :
Basal FSH >10 IU/L, serum prolactin P40
ng/ml, tubal or male factor infertility,
and history of ovulation induction in the
past 3 months. According to these strict
selection criteria these
patients had class II anovulation (eugonadotropic,
normoprolactinemic)
according to WHO classication.

A : dibagi secara acak menggunakan

komputer hingga masing-masing
kelompok berisi 30 orang
M:
Kelompok KS : diberi KS 100 mg/hari
selama 5 hari,
Kelompok kontrol : diberi plasebo yang
mirip penampilan dengan KS

BM : Blinded
OM :
Patients were followed by follicle scanning in the
hospital infertility unit by a limited number of
blinded senior sonographers according to the unit
schedule starting the day after the end of treatment.
The frequency of follicle scanning was tailored till
dominance was conrmed or excluded. Dominance
was dened as a follicle diameter P14 mm.
Progesterone was assayed one week after presumed
ovulation or two weeks after the last bservation in
presumed anovulatory cases. Ovulation
was predicted by the presence of dominant follicle
P14 mm and was conrmed by serum progesterone
P7 ng/ml.

AN:
Kelompok KS yang mengalami kista
ovarium persisten: 9 sampel (30%)
Kelompok KS yang mengalami kista
ovarium persisten: 2 sampel (6,7%)
P = 0,006