Beruflich Dokumente
Kultur Dokumente
Kidneys
Ureters
Urinary bladder
Urethra
Components of nepheron
Renal corpuscle
a)
b)
Bowmans capsule
Glomerulus
Renal tubule
PCT
Loop of henle
Thin descending loop of Henle
Thick ascending loop of Henle
DCT
Collecting duct
Glomerular filtration
Tubular secretion
Tubular re-absorption
Diuretic Drugs
These are drugs which increase the rate of
urine flow and sodium excretion and are used
to adjust the volume and/or composition of
body fluids in a variety of clinical situations,
including:
Hypertension, heart failure, renal failure, and
liver cirrhosis
To induce diuresis
To facilitate the flow of fluid in edema (udder
edema, cerebral edema, glaucoma)
Hypertension
Hyperaldosteronism
Congestive heart failure (CHF)
Brisket edema
Udder edema
Glaucoma
Cerebral edema
Hypertension
Acetozolamide
blood volume BP
Acetozolamide
Na+-H+ antiporter
Na+-HCO3- symporter
Na+
Na+
H+
H+
HCO3-
H2CO3
CA
CO2 + H2O
Lumen
Na
Na+
HCO3-
CA inhibitor
HCO3-
H2CO3
CA
CO2+ H2O
Blood
Clinical uses:
Hydrocephalus (cerebral edema)
Glaucoma
To enhance urination
Adverse effect:
Systemic acidosis (due to reduced level of
bicarbonate in the plasma)
2. Osmotic diuretics
Glycerol
Mannitol
Site of action: Thin descending loop of Henle
Mode of action:
3. Loop diuretics
Frusemide/Furosemide (Lasix)
Ethacrynic acid
Site of action: Thick ascending loop of Henle
Mode of action: Block the action of Na+/K+/2Cl
symport system
Loop diuretics
(Furosemide, Bumetanide, Ethacranic acid)
Na+-K+-2Cl- symport
Loop diuretics
Na+
K+
Cl-
Na+
K+
Cl-
K+
K+
ATPase
Na+
Cl-
K+ Channel
Lumen
Cl- Channel
Blood
Effects:
Diuresis
Natriuresis
Kaliuresis
Adverse effects:
Ototoxicity
Nephrotoxicity
Hypokalemia
4. Thiazide diuretics
Chlorothiazide
Hydrochlorothiazide
Site of action: DCT
Mode of action: Block Na+/Cl- symport system
Effects:
Diuresis
Natriuresis
Commonly used to treat udder edema
Thiazide diuretics
Na -Cl symporter
+
K+ Channel
Na+ pump
(Na+-K+ ATPase)
Thiazide
Na+
Na+
Cl-
Na+
K+
K+ Channel
Lumen
K+
ATPase
ClK+
K+
Cl-
Cl- Channel
Blood
Thiazide diuretics
Adverse effects
Hypercalcemia
Hyperglycemia
Contraindications:
Gout
Diabetes mellitus
Spironolactone binds to MR
& prevent AL action
Spironolactone
(Aldosterone receptor antagonist)
MR
Spironolactone
mRNA
Nucleus
Amiloride
AL
MR-AL
Na+-K+ ATPase
AIP
Na+ Channel
Na+
K+
Lumen
Na+
Na+
K
ATPase
K+
Blood
Adverse effects:
Impairment of the receptor occupancy of
testosterone and progesterone
Can cause sexual dysfunction in case of
overdosage or prolonged use