OSH STATE UNIVERSITY

INTERNATIONAL MEDICAL
FACULTY
CLASS- 3rd YEAR 6-B
TEACHER NAME- SEITOVA A.
SUBJECT- PHARMACOLOGY
TOPIC-ANTIGOUT DRUGS

GOUT
TALATI MOHAMMEDKHUZAIMA
DIPENDRA THALOR
MOHIT RULANYA

INTRODUCTION:
GOUT is known as the disease of kings and rich
mans disease.
Gout(also known aspodagrawhen it involves the
big toe)sa
it is amedical condition usually characterized by
recurrent attacks of acuteinflammatory arthritis-red,
tender, hot,swollen joints
Gout is a kind of arthritis that occurs when uric acid
builds up in blood and causes joint inflammation.
Gout effects more men then woman in them occurs
after menopause
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CAUSES

Hyperuricemiais the underlying cause of gout.

diet, genetic predisposition, or underexcretion ofurate
Low uric acid level in blood
the exact cause is unknown.
Partly genetic cause in the genes contributing to about
60% ofvariabilityin uric acid level
ThreegenesSLC2A9,SLC22A12andABCG2have been
found to commonly be associated with gout, and
variations in them can approximately double the risk
Loss of function mutations inSLC2A9andSLC22A12cause
hereditary hypouricaemia by reducing urate absorption
and unopposed urate secretion

SYMPTOMS

gouty arthritis
Acute gouty arthritis in big toe(podagra)
Kidney stones
Acute pain in joints
Uric acid crystal depositon in the form of tophi
Tophi in ear lobe, achilles ankle and elbow
Fatigue
Mailase
High uric acid levels

TYPES OF GOUT
Depending upon the symptoms and
severity of disease gout is classified
into
Acute gout
Chronic gout

ACUTE GOUT
Acute gout is a painful condition that typically affects
one joint
Symptoms usually involve only one or a few joints. The
big toe, knee, or ankle joints are most often affected.
throbbing, crushing, or excruciating pain
joint appears warm and red
fever.
The attack may go away in a few days, but may return
from time to time. Additional attacks often last longer.
After a first gouty attack, people will have no
symptoms. Half of patients have another attack.

CHRONIC GOUT
Those with chronic arthritis symptoms
include:
joint damage and
loss of motion in the joints.
joint pain and other symptoms most of the
time.
Tophi below the skin around joints or in
other places. Tophi usually develop only
after a patient has had the disease for many
years.

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TREATMENT

NSAID,s
Colchicine
Uricosuric agents
Allopurinol

COLCHICINE
Produces its antiinflammatory effects by
binding to the intracellular
protein tubulin, preventing its
polymerization leading to the
inhibition of leukocyte
migration into affected area.
Inhibits the synthesis &
release of leukotrienes.

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ALLOPURINOL
Inhibits synthesis of
uric acid by
inhibiting xanthine
oxidase enzyme

NSAIDS:
Inhibits pain &
inflammation.
Inhibits urate
crystal phagocytosis
by decreasing the
migration of
granulocytes into
the inflammatory
area.
Indomethacin

URICOSURIC
AGENTS:
Probenecid &
Sulfinpyrazone
They are weak
organic acids
.Sulfinpyrazone is
a metabolite of
phenylbutazone.

CONTINUED

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