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TRANSPORT
Disusun Oleh:
Husnil Kadri
Biochemistry Departement
Medical Faculty Of Andalas
University
Oxygen Transport
AttheLungLevel
AttheTissueLevel
Hemoglobin
Each heme molecule is capable of binding with
1 O2 molecule and each globin molecule is
capable of binding with 1 CO2 molecule.
So, each molecule of Hb can bind 4 molecules
of O2 and 1 molecule of CO2
100 ml of blood has about 15 gr of Hb, at Hct =
0.45
Hb O2 HbO2
HbO2 O2 Hb(O2 ) 2
Hb(O2 ) 2 O2 Hb(O2 ) 3
Hb(O2 ) 3 O2 Hb(O2 ) 4
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Oxygen as Oxyhemoglobin
Each gram of Hb can store about 1.34 ml
of O2:
1 L of blood (150 gr of Hb) can store about
208 ml of O2 Oxygen Capacity of Hb.
With normal cardiac output, about 1040 ml
of O2 can be carried in blood per minute. (4
times of the metabolic demands).
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O2 Saturation.
Units: percent.
Fraction or percentage of all the
hemoglobin binding sites that are
currently occupied by oxygen.
Oxygen Saturation of Hb
O 2 combined with Hb
SHbO2 (% saturation)
100
O 2 capacity of Hb
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Exercise
Increase temperature
Increased PCO2 and
Decreased pH (acidosis)
2,3-DPG
2,3-DPG is a glycolytic intermediate
accumulates to uniquely high levels in RBCs
-Increased 2,3-DPG
-Decreased 2,3-DPG
right shift
left shift
Carbon Dioxide
Transport
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AttheTissueLevel
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AttheLungLevel
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Bicarbonate in RBCs.
Carbonic anhydrase is present in RBCs
CO2 forms carbonic acid which
dissociates to H+ and HCO3CO 2 H 2 O
H 2 CO 3
H HCO 3
Carbonic Anhydrase
PercentofthetotalPaCO2:70%
PercentofthetotalPaCO2:23%
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References
BIOEN
589:
Integrative
Physiology.
Download
24 jan 05.
Kennelly, PJ., Rodwell, V W. Proteins: Myoglobin & Hemoglobin. In:
Harpers Illustrated Biochemistry. 27th Ed. 41- 8.
Miliefsky, M. Respiratory System Ch.23. Download 24 Nov 10.
Sheardown, H. Blood Biochemistry. McMaster University. Download
20 Mei 07.
Irvin, CG. Respiratory Physiology. Lecture 4A CO2 Transport. In:
MEDICAL PHYSIOLOGY 30. Download 22 Jun 09.
Marks, DB., Marks, AD., Smith CM. Basic medical biochemistry: a
clinical approach. 1996. Dalam: B.U. Pendit, penerjemah. Biokimia
Kedokteran Dasar: Sebuah Pendekatan Klinis. Eds. J. Suyono., V.
Sadikin., L.I. Mandera. Jakarta: EGC, 2000
R.K. Murray, D.K. Granner, P.A. Mayes, V.W. Rodwell Harpers
Biochemistry. 27th ed. McGraw-Hill Companies, New York. 2006.
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