Graduate School of Business Graduate School of Business Stanford University Columbia University Motivation: Biopharmaceuticals 1990 BI builds capacity for tPA Activase, plans $1 B revenue Mid-90s drug fails, BI sells plant to Immunex at a loss Late 90s unanticipated success of Enbrel, Rituxan, etc. Dosing 10-100 times greater than expected 3-4 year leadtime to build capacity, obtain FDA approval Lonza, BI: reserve capacity 3 years in advance, steep fees some firms drop or postpone promising drug R&D projects Contract Manufacturing of Biologics
biotech firms realize
renegotiation production invest in R+D contract demand
Lonza builds capacity
capacity allocation
+ efficient capacity utilization, pool uncertain demands
-? Contract Manufacturing of Biologics
biotech firms realize
renegotiation production invest in R+D contract demand
Lonza builds capacity
capacity allocation
Watch Out for Hold Up Problem (Plambeck & Taylor, 2001) :
Outsourcing profit if buyer is powerful, e.g. CM has excess capacity or competition or needs future business Otherwise, firms should own capacity Contract to pool capacity: STRATEGIC and EARLY Contract Manufacturing of Biologics
biotech firms realize
renegotiation production contract invest in R+D demand
Lonza builds capacity
capacity allocation
CHALLENGE: Design supply contracts that induce first best
innovation and capacity investment (max. total expected profit)
SURPRISE: Often, simple reservation contracts are optimal:
depends on remedy for breach of contract, bargaining power assumes common information (Plambeck & Taylor, 2003) Court Remedies for Breach of Contract
Specific Performance Expectation Damages
must perform contract pay $ to put injured firm in (prohibitively large $ penalty) same financial position as if contract were performed manufacturer must deliver Q manufacturer can deliver < unless buyer agrees to less Q , pay for lost revenue or substitute capacity awarded on discretionary routine in procurement basis for unique items Literature Review Efficient breach theory: ED remedy encourages promisors breach where the resulting profits to promisor exceed loss to promisee (Holmes, 1881)
Econ and supply chain lit implicitly assumes SP
Scholars begin to advocate routine availability of SP:
efficient breach with SP through renegotiation ED is complex, undercompensatory(Varadarjan,2001) ED skews investment (Edlin&Reichelstein,1996)
Firms use reputation/relational contract to guarantee SP
Conclusions
Expectation Specific Damages Performance
powerful first best with simple excess capacity,
manufacturer reservation contracts too little R&D
buyers have too little capacity, first best with simple
some excess R&D reservation contracts* bargaining power tradable options Qi profit E[share of optimal capacity] * requires separability condition Ongoing Research
Contract EARLY to avoid Hold Up
In designing supply contract, anticipate renegotiation
Outcome of renegotiation depends on court remedy for
breach of contract (even if we never go to court)
Specific performance remedy may become routine
Ongoing Research on Outsourcing
Information asymmetry
Relational contracts (enforced by value of future
business, not the courts)
Scope of responsibility for CM: design? procurement?